In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Aliya KassenovaCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, 010000 Astana, Kazakhstan.ORCID 0000-0002-3670-3600 Evgeniy SvirinCenter for Neurocognitive Research (MEG-Center), Moscow State University of Psychology and Education, 123290 Moscow, Russia.ORCID 0000-0003-3501-574X Kseniia SitdikovaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 119071 Chernogolovka, Russia.ORCID 0000-0001-8870-7403 Kirill ChaprovInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 119071 Chernogolovka, Russia.ORCID 0000-0002-0258-1879 Andrey TsoyCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, 010000 Astana, Kazakhstan.ORCID 0000-0003-3818-3079 Anuar NurzhanovDepartment of Biology, School of Sciences and Humanities, Nazarbayev University, 010000 Astana, Kazakhstan.ORCID 0009-0002-1486-1496 Maria KuznetsovaDepartment of Normal Physiology, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.ORCID 0009-0003-9971-0538 Tatyana VeremeykoDepartment of Biology, School of Sciences and Humanities, Nazarbayev University, 010000 Astana, Kazakhstan.
Alexey DeykinLaboratory of Genetic Technology and Gene Editing for Biomedicine and Veterinary, National Research Belgorod State University, 308015 Belgorod, Russia.
Eugene PonomarevDepartment of Biology, School of Sciences and Humanities, Nazarbayev University, 010000 Astana, Kazakhstan.
Tatyana StrekalovaDepartment of Psychiatry and Neuropsychology, Maastricht University, Universiteitsinsel 50, 6229 ER Maastricht, The Netherlands.
Sholpan AskarovaCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, 010000 Astana, Kazakhstan.ORCID 0000-0001-6161-1671 Funding
Ministry of Science and Higher Education of the Republic of Kazakhstan AP23485236Scientific state assignment to the Centre for Collective Use IPAC RAS FFSG-2024-0020The Faculty Development Competitive Research Grant Program, Nazarbayev Fund, Nazarbayev University Ref. No. 201223FD8829The Marie Skłodowska-Curie Aqua-Synapse project within the European Union's Horizon 2020 research and innovation program (H2020-MSCA-RISE-2020) 101086453EUThe Marie Skłodowska-Curie PhytoApp within the European Union's Horizon 2020 research and innovation program (H2020-MSCA-RISE-2020) 101007642EUThe Scientific state assignment FZWG-2024-0003
6 · The paper itselfAbstract
Growing evidence suggests an important pathogenetic role of brain-specific gangliosides in the mechanisms underlying Alzheimer's disease (AD), the most common form of dementia. Nutritional strategies targeting ganglioside sialylation-for example, through agglutinin-mediated modulation-have therefore attracted increasing research interest. In particular, wheat malt extract (WME), a food-derived source of wheat germ agglutinin (WGA) with high affinity for gangliosides, may influence molecular pathways involved in AD pathogenesis. Twelve-month-old female APPswe/PS1E9 transgenic mice, a model of AD, and wild-type (WT) littermates received WME or tap water for three weeks. Behavioral performance was subsequently assessed. Amyloid plaque burden and astrocyte activation were evaluated using Congo red staining and GFAP immunoreactivity, respectively. Gene expression of selected AD markers in the brain was quantified by RT-qPCR. Aged WT mice exhibited robust, region-specific molecular responses to WME, including upregulation of activity-dependent and synaptic plasticity genes (
Indexed as
AgingAlzheimer DiseaseAmyloid beta-Protein PrecursorBehavior, AnimalPlant ExtractsPresenilin-1TriticumAnimalsAstrocytesBiomarkersBrainDisease Models, AnimalFemaleMiceMice, TransgenicPlaque, AmyloidAmyloid beta-Protein PrecursorBiomarkersPlant ExtractsPresenilin-1Wheat Germ AgglutininsAlzheimer’s diseaseAPPswe/PS1E9 micewheat germ agglutininwheat malt extract
Identifiers
PMID42278520
PMCPMC13256562
What Socratic holds
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