ReviewInternational journal of molecular sciences2026
Decoding Cyclodextrins in Skin Applications: Structure, Mechanisms, and Safety in Cosmetic and Dermatologic Formulations (Part I).
Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
9 authors.
Funding
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Abstract
Cyclodextrins (CDs) have emerged as important encapsulation platforms in dermatologic and cosmetic sciences, addressing critical challenges related to the solubility and stability of bioactive compounds. This review (Part I) systematically explores the relationship between the molecular architecture of CDs and their functional performance at the skin interface. A comprehensive analysis of the physicochemical properties of natural and derivative cyclodextrins is presented, alongside an evaluation of their interaction mechanisms with the skin barrier and current regulatory frameworks. This study highlights how the hydrophobic cavity of CDs enables the successful encapsulation of botanical extracts, significantly enhancing their bioavailability and photostability. Furthermore, the mechanistic insights provided clarify how appropriately selected and formulated CDs can modulate skin penetration while maintaining acceptable epidermal barrier compatibility. A critical synthesis of safety data and toxicological profiles confirms the suitability of specific CD types for topical application, supported by an overview of the evolving European and international legislative landscapes. Understanding the molecular design and safety constraints of cyclodextrin-based systems is essential for developing next-generation dermocosmetics. This foundational analysis provides the necessary framework for the clinical and technological applications discussed in the subsequent part of this review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.