ArticleHealthcare (Basel, Switzerland)2026
Clinical, Neuropathic, and Sudomotor Correlates of Orthostatic Hypotension in Type 2 Diabetes: A Cross-Sectional Study.
Article in Healthcare (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesOrthostatic hypotension (OH) is a clinically relevant manifestation that may reflect cardiovascular autonomic dysfunction in type 2 diabetes (T2D), yet its correlates remain incompletely characterized. This cross-sectional study evaluated clinical, neuropathic, and sudomotor factors associated with OH and explored balance-related outcomes as secondary analyses.
methodsIn this cross-sectional study, 124 adults with T2D aged ≥60 years underwent standardized orthostatic blood pressure testing. Peripheral neuropathy was assessed using the Michigan Neuropathy Screening Instrument (MNSI), and sudomotor function was assessed by electrochemical skin conductance measured with Sudoscan. Balance, mobility, and fear of falling were evaluated as exploratory secondary outcomes. Active antihypertensive treatment was recorded at the time of assessment and considered a potential confounder. Multivariable logistic regression was used to identify factors associated with OH.
resultsOH was associated with longer diabetes duration (OR = 1.11/year,
conclusionsIn older adults with T2D, OH was associated with longer disease duration, greater neuropathy burden, and microvascular involvement. Sudoscan-derived measures were not independently associated with OH in this cohort. Because of the cross-sectional design and residual medication confounding, all findings should be interpreted as associations only. These results support routine orthostatic evaluation alongside neuropathy and albuminuria assessment, while predictive modeling requires external validation in larger cohorts.
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