Evidence map›Paper›PMID 42279271›Full record

ArticleCancers2026

Clinical Impact of Baseline ctDNA

Takeshi Yamada, Takeshi Nagasaka, Nobuhisa Matsuhashi, Takao Takahashi, Keiji Hirata, Yuki Nakamura, Kiichi Sugimoto, Keiji Koda, Kazuhiro Hiramatsu, Hiroshi Matsuoka and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Takeshi YamadaDepartment of Gastroenterological Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.ORCID 0000-0002-1436-7482
Takeshi NagasakaDepartment of Advanced Oncology, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Japan.ORCID 0000-0002-4236-350X
Nobuhisa MatsuhashiDepartment of Gastroenterological Surgery and Pediatric Surgery, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.
Takao TakahashiDepartment of Surgery, Seino Kosei Hospital, Gifu Seino Medical Center, 293-1 Shimoiso, Ohno-cho, Gifu 501-0532, Japan.
Keiji HirataDepartment of Surgery 1, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.ORCID 0000-0001-6461-5109
Yuki NakamuraSecond Department of Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan.
Kiichi SugimotoDepartment of Coloproctological Surgery, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.ORCID 0000-0003-1210-2920
Keiji KodaDepartment of Surgery, Faculty of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.ORCID 0000-0001-6073-9104
Kazuhiro HiramatsuDepartment of General Surgery, Toyohashi Municipal Hospital, 50 Aza Hachiken-nishi, Aotake-cho, Toyohashi 441-8570, Japan.
Hiroshi MatsuokaDepartment of Gastrointestinal Surgery, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan.ORCID 0000-0002-7837-565X
Hidekazu KuramochiDepartment of Medical Oncology, NTT East Japan Kanto Hospital, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo 141-8625, Japan.
Akihisa MatsudaDepartment of Gastroenterological Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.ORCID 0000-0002-6468-9375
Hideyuki IshidaDepartment of Digestive Tract and General Surgery, Saitama Medical University General Medical Center, 1981 Kamoda, Kawagoe 350-8550, Japan.
Kozo KataokaDivision of Lower GI Surgery, Department of Gastroenterological Surgery, Hyogo Medical University, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan.
Hajime YokomizoDepartment of Surgery, Tokyo Women's Medical University Adachi Medical Center, 4-33-1 Kohoku, Adachi-ku, Tokyo 123-8558, Japan.
Yoshinori KagawaDepartment of Gastroenterological Surgery, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka 541-8567, Japan.
Mitsukuni SuenagaDepartment of Clinical Oncology, Institute of Science Tokyo, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan.ORCID 0000-0002-6634-2893
Hiroshi YoshidaDepartment of Gastroenterological Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.

Funding

Grants-in-Aid for Scientific Research 22K08787
6 · The paper itself

Abstract

Epidermal growth factor receptor (EGFR) blockade combined with cytotoxic chemotherapy has substantially improved outcomes in unresectable metastatic colorectal cancer (mCRC), particularly in patients with left-sided

Indexed as

BRAFconversion surgeryctDNAEGFR blockadeliquid biopsymetastatic colorectal cancerRAS

Identifiers

PMID42279271
PMCPMC13255658

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.