Hemp Seed Protein-Derived Lipase Inhibitory Peptides Attenuate High-Fat Diet-Induced Obesity: Evidence from Intestinal Fat Digestion and Gut-Liver Axis Regulation.

Hao Yin, Jiangxiong Zhu, Ruilong Luo, Yu Zhong, Ting Zhao, Minyan Zhang, Yun Deng

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Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Hao YinDepartment of Food Science & Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.ORCID 0000-0002-9334-6937

Jiangxiong ZhuDepartment of Food Science & Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.ORCID 0009-0005-7659-6175

Ruilong LuoEryuan County Inspection and Testing Institute, Dali 671299, China.

Yu ZhongDepartment of Food Science & Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.

Ting ZhaoYunnan Dali Research Institute of Shanghai Jiao Tong University, Dali 671000, China.

Minyan ZhangEryuan County Inspection and Testing Institute, Dali 671299, China.

Yun DengDepartment of Food Science & Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.ORCID 0000-0003-0647-3151

Funding

Yunnan Fundamental Research Projects 202301AS070014

6 · The paper itself

Abstract

Obesity and its metabolic complications represent a major global health challenge, and food-derived bioactive peptides are emerging as promising dietary interventions. In this study, two hemp seed protein-derived tetrapeptides with pancreatic lipase (PL) and cholesterol esterase (CE) inhibitory activity, APAM and RLPA, were co-administered with a high-fat diet (HFD) to male C57BL/6J mice at 25 and 100 mg/kg body weight for 10 weeks. Both peptides dose-dependently alleviated HFD-induced body weight gain, visceral fat accumulation, hepatic steatosis, dyslipidemia, hyperglycemia, and systemic inflammation. Mechanistically, both peptides inhibited intestinal PL and CE activities and enhanced fecal lipid excretion, supporting direct suppression of intestinal fat digestion. 16S rRNA gene sequencing revealed partial restoration of HFD-disrupted gut microbiota, with APAM preferentially enriching

Indexed as

anti-obesitybioactive peptidesgut-liver axisgut microbiotahemp seed proteinpancreatic lipase inhibition

Identifiers

PMID42279825

DOI10.3390/foods15112040

PMCPMC13257395

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Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.