ArticleMolecules (Basel, Switzerland)2026
Mechanism of Mutation in G Protein-Gated Inwardly Rectifying K
Asmaa S AbuMaziad, Julia J Liang, Alex N O Logothetis, Eleni Pitsillou, Andrew Hung, Jordan Beck, Rissa Zudekoff, Autri Hafezi, Bruce Chy, Abigail Slack and 3 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Asmaa S AbuMaziadDepartment of Pediatrics, Division of Nephrology, University of Arizona College of Medicine, Tucson, AZ 85724, USA.ORCID 0000-0001-5093-3405 Alex N O LogothetisEpiMed Centre, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.
Eleni PitsillouEpiMed Centre, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.
Jordan BeckDepartment of Pediatrics, Division of Nephrology, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Rissa ZudekoffDepartment of Pediatrics, Division of Nephrology, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Autri HafeziDepartment of Pediatrics, Division of Nephrology, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Bruce ChyDepartment of Pediatrics, Division of Nephrology, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Abigail SlackDepartment of Pediatrics, Division of Nephrology, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
AbdAssalam QannusDepartment of Medicine, Division of Nephrology, University of Arizona Health Sciences, Tucson, AZ 85721, USA.
Assam El-OstaEpigenetics in Human Health and Disease Program, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.ORCID 0000-0001-7968-7375 Funding
Australian Education Research Organisation Australian Government Research Training Program ScholarshipDoris Duke Charitable Foundation Grant 2021263 (4258021/FUTR1)University of Arizona CDA-2123691-CDA39University of Arizona PANDA, Steele Children's Research Center (PANDA), Department of Pediatrics
6 · The paper itselfAbstract
Primary aldosteronism (PA) is the most common cause of secondary hypertension and accounts for 5-15% of hypertensive patients. Familial hyperaldosteronism, a monogenic cause of PA, accounts for ~1-5% of cases. Familial hyperaldosteronism type III results from mutations in the
Indexed as
G Protein-Coupled Inwardly-Rectifying Potassium ChannelsHyperaldosteronismMutationHumansMolecular Dynamics SimulationProtein ConformationG Protein-Coupled Inwardly-Rectifying Potassium ChannelsKCNJ5 protein, humanfamilial hypertensionGIRK4G protein-activated inward-rectifier potassium channelhypertensionKCNJ5primary aldosteronism
Identifiers
PMID42280146
PMCPMC13258295
What Socratic holds
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