ArticleMolecules (Basel, Switzerland)2026
Gold Nanoparticle Complexes with PAMAM Dendrimers for In Vitro Cancer Cytotoxicity Assessment: Synthesis via Ascorbic Acid Reduction.
Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The Mechanism and Application of Traditional Chinese Medicine Nano-Formulations in the Treatment of Renal Fibrosis.International journal of nanomedicine · 2026Review
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3 authors.
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Abstract
Ascorbic acid plays an important role in the human body due to its antioxidant and anti-inflammatory properties, as well as its involvement in collagen synthesis, enzymatic regulation, and the biosynthesis of corticosteroids and selected neurotransmitters. Owing to these diverse functions, it is used both in the prevention and supportive treatment of several disorders and as a mild, non-toxic reducing agent in the synthesis of gold nanoparticles (AuNPs). In the present study, a method for synthesizing gold nanoparticles was developed using second-generation poly(amidoamine) dendrimers (PAMAM G2) with an ethylenediamine core as stabilizing agents and ascorbic acid as the reducing agent. The synthesis was performed using two techniques: sonication and microwave irradiation. A comparative analysis was conducted for colloidal systems obtained at various molar ratios of PAMAM G2 dendrimers to chloroauric acid (ranging from 1:1 to 1:5). The presence of gold nanoparticles was confirmed using ultraviolet-visible spectroscopy (UV-Vis). Nanoparticle diameters and zeta potentials were determined by dynamic light scattering (DLS). The sizes of the metallic cores were estimated using scanning transmission electron microscopy (STEM). Furthermore, the morphology and topography of entire complexes deposited on silicon substrates were visualized using atomic force microscopy (AFM). For cytotoxicity studies on human breast adenocarcinoma and human osteosarcoma cell lines, the most stable colloids-those obtained at a PAMAM G2:HAuCl
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