Evidence mapPaperPMID 42280247Full record

ArticleMolecules (Basel, Switzerland)2026

An Approach Toward Radioiodination and Radiopharmacological Evaluation of a Carborane-Containing Analog of Indomethacin.

Jonas Schädlich, Christoph Selg, Cathleen Haase-Kohn, Martin Ullrich, Robert Wodtke, Klaus Kopka, Evamarie Hey-Hawkins, Jens Pietzsch, Markus Laube

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jonas SchädlichInstitute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstraße 400, 01328 Dresden, Germany.ORCID 0009-0002-4550-0394
Christoph SelgInstitute of Bioanalytical Chemistry, Centre for Biotechnology and Biomedicine (BBZ), Faculty of Chemistry and Mineralogy, Leipzig University, Deutscher Platz 5, 04103 Leipzig, Germany.ORCID 0009-0003-8925-8090
Cathleen Haase-KohnInstitute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstraße 400, 01328 Dresden, Germany.ORCID 0000-0002-5032-5095
Martin UllrichInstitute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstraße 400, 01328 Dresden, Germany.ORCID 0000-0001-6104-6676
Robert WodtkeInstitute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstraße 400, 01328 Dresden, Germany.ORCID 0000-0001-7462-7111
Klaus KopkaInstitute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstraße 400, 01328 Dresden, Germany.ORCID 0000-0003-4846-1271
Evamarie Hey-HawkinsInstitute of Bioanalytical Chemistry, Centre for Biotechnology and Biomedicine (BBZ), Faculty of Chemistry and Mineralogy, Leipzig University, Deutscher Platz 5, 04103 Leipzig, Germany.ORCID 0000-0003-4267-0603
Jens PietzschInstitute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstraße 400, 01328 Dresden, Germany.ORCID 0000-0002-1610-1493
Markus LaubeInstitute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstraße 400, 01328 Dresden, Germany.ORCID 0000-0003-4916-3794

Funding

Bundesministerium für Forschung, Technologie und Raumfahrt 031L0258BDeutsche Forschungsgemeinschaft HE 1376/54-1Deutsche Forschungsgemeinschaft PI 304/7-.1Deutsche Forschungsgemeinschaft SFB/TRR 205/2, No. 314061271European Union NextGenerationEURomanian Ministry of Research, Innovation and Digitalization PNRR-III-C9-2023-I8-CF76, contract nr. 760240/28.12.2023
6 · The paper itself

Abstract

Dicarbadodecaboranes (12) (carboranes) are versatile molecular building blocks with unique properties, which allow the expansion of classical medicinal-chemical space. To enable single-photon emission computed tomography (SPECT) imaging of cyclooxygenase-2 (COX-2), we investigated the feasibility of introducing iodine-123 into

Indexed as

BoranesCyclooxygenase 2 InhibitorsIndomethacinIodine RadioisotopesRadiopharmaceuticalsAnimalsCarboranesCyclooxygenase 2HalogenationHumansMiceMicrosomes, LiverTissue DistributionTomography, Emission-Computed, Single-PhotonBoranesCarboranesCyclooxygenase 2Cyclooxygenase 2 InhibitorsIndomethacinIodine-123Iodine RadioisotopesRadiopharmaceuticalscyclooxygenasedicarbadodecaboraneiodine-123SPECT imaging

Identifiers

PMID42280247
PMCPMC13257756

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.