Integrative Pan-Cancer Mapping of Proteasome Dependency Prioritizes PSMB5 and PSMB6 as Context-Dependent Vulnerability Biomarkers Linked to Immune Context.

Jeong Han Kim, Hansol Park, Hyo Jin Kim, Myoung-Eun Han, Dongjun Lee, Sik Yoon, Sae-Ock Oh

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jeong Han KimDepartment of Anatomy, School of Medicine, Pusan National University, 49 Busandaehak-ro, Yangsan 50612, Republic of Korea.

Hansol ParkDepartment of Anatomy, School of Medicine, Pusan National University, 49 Busandaehak-ro, Yangsan 50612, Republic of Korea.

Hyo Jin KimDepartment of Anatomy, School of Medicine, Pusan National University, 49 Busandaehak-ro, Yangsan 50612, Republic of Korea.

Myoung-Eun HanDepartment of Anatomy, School of Medicine, Pusan National University, 49 Busandaehak-ro, Yangsan 50612, Republic of Korea.ORCID 0000-0001-6083-0485

Dongjun LeeResearch Center for Molecular Control for Cancer Cell Diversity, Pusan National University, Yangsan 50612, Republic of Korea.ORCID 0000-0001-6828-401X

Sik YoonDepartment of Anatomy, School of Medicine, Pusan National University, 49 Busandaehak-ro, Yangsan 50612, Republic of Korea.ORCID 0000-0002-6449-0761

Sae-Ock OhDepartment of Anatomy, School of Medicine, Pusan National University, 49 Busandaehak-ro, Yangsan 50612, Republic of Korea.

Funding

National Research Foundation (NRF) funded by the Korean government (MSIT) NRF-2022R1A5A2027161, NRF-2022R1A2C1003930, 1465033773

6 · The paper itself

Abstract

The prioritization of biomarkers that inform molecular-targeted cancer research remains challenging because tumor vulnerabilities are context-dependent. The ubiquitin-proteasome system is essential for cancer cell survival; however, the functional and biomarker-level relevance of individual proteasome subunits has not been systematically defined across cancer types. In this study, we performed an integrative pan-cancer analysis to prioritize proteasome subunits that function as context-dependent vulnerability biomarkers. We analyzed proteasome subunits and proteasome-associated genes across 54 cancer types by integrating large-scale CRISPR (

Indexed as

Biomarkers, TumorNeoplasmsProteasome Endopeptidase ComplexCell Line, TumorGene Expression Regulation, NeoplasticHumansBiomarkers, TumorProteasome Endopeptidase ComplexPSMB5 protein, humanbiomarkercancer dependencyimmune infiltrationmolecular-targeted therapypan-cancer analysisproteasome subunitsPSMB5PSMB6

Identifiers

PMID42280256

DOI10.3390/molecules31111954

PMCPMC13258478

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.