Evidence map›Paper›PMID 42280319›Full record

Trial reportNutrients2026

Multimodal Nutraceutical and Psychological Intervention for GGT Reduction in Individuals with Alcohol Use Disorder.

Nilca Stefania Diana, Tarcea Monica, Gliga Florina

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07603726 (Multimodal Nutraceutical and Psychological Intervention for GGT Reduction in Individuals With Alcohol Use Disorder), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07603726 nacompletednot on this map

Multimodal Nutraceutical and Psychological Intervention for GGT Reduction in Individuals With Alcohol Use Disorder

TypeinterventionalSponsorMedical Center TOPMEDRan2024 to 2026Enrolled197ConditionsAlcohol Use Disorder (AUD)ArmsAlcohol Reduction Counseling, Nutraceutical Treatment, Psychological Intervention
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nilca Stefania DianaDoctoral School, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Târgu Mureș, Romania.ORCID 0009-0006-1136-168X
Tarcea MonicaDepartment of Community Nutrition and Food Safety, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Târgu Mureș, Romania.ORCID 0000-0001-7299-118X
Gliga FlorinaDepartment of Physiopathology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Târgu Mureș, Romania.ORCID 0000-0002-0356-822X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElevated gamma-glutamyl transferase (GGT) is a biomarker associated with alcohol-related hepatic stress and oxidative imbalance. Although alcohol abstinence is the primary determinant of GGT normalization, adjunctive strategies may support biochemical improvement in real-world settings.

methodsThis non-randomized cohort study included 197 of 1957 screened participants (10.1%), stratified according to baseline GGT into 55-99 U/L ( CLINICAL

trial registrationClinicalTrials.gov Identifier: NCT07603726.

resultsAmong participants with baseline GGT ≥ 100 U/L, GGT levels decreased from a median of 133.73 to 97.41 U/L (

conclusionsIn this real-world cohort, reductions in GGT levels were observed, particularly among individuals with elevated baseline values (≥100 U/L) who underwent the multimodal intervention. These findings support monitoring GGT dynamics in routine clinical practice, where GGT remains a practical and accessible biomarker due to its widespread availability, low cost, and sensitivity to oxidative and alcohol-related hepatic stress.

Indexed as

AlcoholismDietary Supplementsgamma-GlutamyltransferaseAdultAlcohol AbstinenceAntioxidantsBiomarkersCohort StudiesFemaleHumansMaleMiddle AgedOxidative StressSilymarinTreatment OutcomeAntioxidantsBiomarkersgamma-GlutamyltransferaseGGT1 protein, humanSilymarinalcohol abstinencealcohol use disordergamma-glutamyl transferasenutraceuticalspsychological intervention

Identifiers

PMID42280319
PMCPMC13257675

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.