Evidence mapPaperPMID 42280440Full record

ReviewNutrients2026

Herbal Neurotherapeutics for Cognitive Disorders: Integrative Mechanisms Linking Neurotransmitter Systems, Neurodegeneration, and the Gut-Brain Axis.

Muntajin Rahman, Khadija Akter, Amama Rani, Moon Nyeo Park, Bonglee Kim

Abstract readReview
In one paragraph

Review in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Muntajin RahmanDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02453, Republic of Korea.
Khadija AkterDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02453, Republic of Korea.
Amama RaniDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02453, Republic of Korea.
Moon Nyeo ParkDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02453, Republic of Korea.ORCID 0000-0002-9276-3894
Bonglee KimDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02453, Republic of Korea.ORCID 0000-0002-8678-156X

Funding

Basic Science Research Program through the National Research Foundation of Korea (NRF), RS-2020-NR054734National Research Foundation of Korea (NRF) grant RS-2020-NR049559
6 · The paper itself

Abstract

Cognitive disorders, including Alzheimer's disease, Parkinson's disease, schizophrenia, depression, and vascular dementia, are associated with dysregulation of neurotransmitter systems, including acetylcholine, dopamine, serotonin, glutamate, and γ-aminobutyric acid (GABA). These disorders are increasingly recognized as multifactorial conditions involving oxidative stress, neuroinflammation, mitochondrial dysfunction, synaptic impairment, blood-brain barrier disruption, metabolic imbalance, and gut-brain axis dysregulation. Current pharmacological therapies may provide symptomatic relief; however, their clinical benefits are often limited and associated with adverse effects. Herbal medicines have gained increasing attention as potential complementary approaches for cognitive support and neuroprotection. Preclinical evidence and emerging clinical studies suggest that herbal bioactive compounds may exert neuroprotective effects through antioxidants, anti-inflammatory, and neurotransmitter-modulating mechanisms. Medicinal herbs such as

Indexed as

Brain-Gut AxisCognition DisordersNeurodegenerative DiseasesNeuroprotective AgentsNeurotransmitter AgentsPhytotherapyPlants, MedicinalAnimalsBrainCognitive EnhancementHumansNeuroprotective AgentsNeurotransmitter Agentsacetylcholinesterase inhibitorsAlzheimer’s diseasesherbal compoundsherbal medicineneurological disordersneurotransmitter pathways

Identifiers

PMID42280440
PMCPMC13259096

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.