Evidence map›Paper›PMID 42280457›Full record

Trial reportNutrients2026

Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial.

Susan Sergeant, Linda H Easter, Tammy Mustin, Priscilla Ivester, Jimaree A Legins, Michael C Seeds, Carrie S Standage-Beier, Anderson Cox, Cristina M Furdui, Brian Hallmark and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02962128 (Role of PUFA-Gene Interactions in Health Disparities), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02962128 nacompletednot on this map

Role of PUFA-Gene Interactions in Health Disparities

TypeinterventionalSponsorWake Forest University Health SciencesRan2016 to 2021Enrolled80ConditionsFatty Acid-Gene InteractionsArmsHigh Linoleic Acid (LA) Diet, Low Linoleic Acid (LA) Diet
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Susan SergeantDepartment of Biochemistry, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA.ORCID 0000-0001-6042-476X
Linda H EasterOffice of Clinical and Academic Research, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA.
Tammy MustinDepartment of Biochemistry, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA.
Priscilla IvesterDepartment of Biochemistry, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA.
Jimaree A LeginsDepartment of Biochemistry, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA.ORCID 0009-0003-7679-3705
Michael C SeedsWake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA.ORCID 0000-0003-4627-4595
Carrie S Standage-BeierSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, AZ 85719, USA.
Anderson CoxProteomics and Metabolomics Shared Resource, Comprehensive Cancer Center, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA.ORCID 0000-0001-5491-1019
Cristina M FurduiDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA.
Brian HallmarkBIO5 Institute, University of Arizona, 1657 E. Helen St., Tucson, AZ 85719, USA.ORCID 0000-0002-6790-0471
Floyd H ChiltonSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, AZ 85719, USA.

Funding

NIH HHS 1R01AT008621-01A1NIH HHS 5UL1TR001420-09
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe modern Western diet (MWD) provides high linoleic acid (LA) exposure, typically contributing 6-9% of the total caloric intake. These high LA levels have fueled a longstanding debate about whether this dietary pattern confers benefit or risk. Importantly, LA intake is disproportionately elevated among lower socioeconomic populations due to greater reliance on industrial seed oils and ultra-processed foods. Despite decades of research, controlled dietary intervention studies directly evaluating the biological consequences of varying LA exposure remain limited.

methodsThe current randomized, double-blind intervention (ClinicalTrials.gov; NCT02962128; 11 November 2016) compared the effects of a 12-week Low-LA diet (2.5% energy) versus a High-LA diet (10.0% energy) in healthy adults. Outcomes included plasma concentrations of highly unsaturated fatty acids (HUFAs) and ex vivo zymosan-stimulated whole-blood oxylipin generation.

resultsFifty-two participants completed the intervention. High LA exposure resulted in marked reductions in plasma

conclusionsHUFA and oxylipin analyses revealed that higher dietary LA markedly increased the ratios of ARA to EPA and ARA- to EPA-derived oxylipin species, shifting the lipid mediator balance toward a more

Indexed as

Eicosapentaenoic AcidLinoleic AcidLipoxygenaseOxylipinsAdultDiet, WesternDouble-Blind MethodFatty Acids, UnsaturatedFemaleHumansMaleMiddle AgedYoung AdultEicosapentaenoic AcidFatty Acids, UnsaturatedLinoleic AcidLipoxygenaseOxylipinsdietary interventioneicosapentaenoic acidinflammationlinoleic acidoxylipins

Identifiers

PMID42280457
PMCPMC13259401

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.