Trial reportNutrients2026
1,5-Anhydro-D-Mannitol Is a Potentially Low-Energy Carbohydrate: A Dual-Model Approach in Rats and a Randomized, Three-Way Crossover Trial in Humans.
Trial report in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
BACKGROUND/
objectivesWe hypothesized that orally ingested 1,5-anhydro-D-mannitol (AM) would be absorbed from the gut but poorly metabolized, and it may have low fermentability by gut microbiota based on the breath hydrogen test.
methodsWe used a dual-model approach in this study. In animal experiments, AM was administered orally to male Wistar rats. In a randomized, three-way crossover trial (UMIN000054040), 15 healthy young adults consumed a single 5 g dose of AM, mannose, or fructooligosaccharide (FOS). Primary outcome was breath hydrogen concentrations; secondary outcomes included plasma AM, blood glucose concentration, and urinary AM excretion.
resultsAfter ingestion of 5 g AM in humans, the 14 h area under the curve for breath hydrogen excretion was markedly lower after AM than that after FOS ingestion (
conclusionsThese findings indicate that AM is potentially a low-energy carbohydrate.
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