Evidence map›Paper›PMID 42280768›Full record

ArticlePlants (Basel, Switzerland)2026

Structure-Based Identification of Allosteric Glucocerebrosidase Stabilizers from

Irshad Ahammed Ebrahim Thaivalappil, Aswin Mohan, Anuroopa G Nadh, Rajesh Raju, Mohammed Gulzar Ahmed

Abstract read
In one paragraph

Article in Plants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Irshad Ahammed Ebrahim ThaivalappilDepartment of Pharmaceutics, Yenepoya Pharmacy College and Research Centre, Yenepoya (Deemed to be University), Mangalore 575018, Karnataka, India.ORCID 0009-0004-2814-7503
Aswin MohanCentre for Integrative Omics Data Science (CIODS), Yenepoya (Deemed to be University), Mangalore 575018, Karnataka, India.
Anuroopa G NadhCentre for Integrative Omics Data Science (CIODS), Yenepoya (Deemed to be University), Mangalore 575018, Karnataka, India.
Rajesh RajuCentre for Integrative Omics Data Science (CIODS), Yenepoya (Deemed to be University), Mangalore 575018, Karnataka, India.ORCID 0000-0003-2319-121X
Mohammed Gulzar AhmedDepartment of Pharmaceutics, Yenepoya Pharmacy College and Research Centre, Yenepoya (Deemed to be University), Mangalore 575018, Karnataka, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease is strongly linked to lysosomal dysfunction, particularly reduced activity of glucocerebrosidase (GCase) encoded by the GBA1 gene. Stabilizing GCase using small-molecule modulators represents a promising therapeutic strategy. In this study, phytochemicals from

Indexed as

allosteric modulatorglucocerebrosidaseLC-QTOF-MSmolecular dockingParkinson’s diseaseXylia xylocarpaα-synuclein

Identifiers

PMID42280768
PMCPMC13258993

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.