ReviewCureus2026
Ceramides and Type 2 Diabetes: A Scoping Review of Mechanisms, Insulin Resistance, and Nutritional Interventions.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This scoping literature review examined the relationship between ceramides and type 2 diabetes mellitus (T2DM), as well as nutrition interventions that are shown to lower circulating ceramides. Ceramides, bioactive sphingolipids implicated in lipid dysregulation, play a critical role in the development of insulin resistance in obesity-related T2DM. Since diet strongly influences ceramide synthesis, targeted nutritional interventions represent a promising strategy to counteract their impact and improve metabolic health. A systematic search following Preferred Reporting Items for Systematic Reviews and Meta-Analyses Scoping Review (PRISMA-ScR) guidelines was conducted across PubMed, Gale Health and Medicine, Google Scholar, and EBSCO for English language articles published between 2000 and 2025. From the initial 70 records, 45 studies were selected using our systematic, rigorous selection criteria. Evidence demonstrated that high-fat diets, in particular saturated fats, elevate plasma ceramide levels, which are strongly associated with insulin resistance and T2DM. Nutrition interventions shown to lower ceramides include limiting saturated fats to less than 6% of total calories, increasing dietary fiber to ≥35 g/day, and following the Diabetes Plate guidelines. Collectively, the evidence supports a mechanistic and associative link between ceramides and T2DM. It highlights the emerging potential of plasma ceramides as biomarkers for insulin resistance and disease risk. Continuing research into nutrition‑based ceramide modulations may inform future diabetes prevention and management strategies.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.