ArticleJournal of arrhythmia2026
Sleep Apnea and Paroxysmal Atrial Fibrillation: Diurnal Patterning of Autonomic Dysfunction and Influence of CPAP Therapy.
Article in Journal of arrhythmia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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11 authors.
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Abstract
Objective: Autonomic nervous system (ANS) dysfunction is implicated in sleep-disordered breathing (SDB) and atrial fibrillation (AF); however, diurnal patterning of ANS function in SDB is unclear. We hypothesize diurnal variation of heart rate variability (HRV) in paroxysmal AF (PAF) in SDB and alteration by continuous positive airway pressure (CPAP). Method: Data from the Sleep Apnea and Atrial Fibrillation Biomarkers and Electrophysiologic Atrial Triggers (SAFEBEAT) study including 7-24 days of electrocardiography (ECG), concomitant actigraphy and polysomnography at baseline and 3 months post-CPAP initiation were analyzed. Linear mixed-effects models were used to assess (1) SDB: apnea hypopnea index (AHI), hypoxia (%sleep time with SaO Results: In 44 869 5-min epochs from 109 participants with SDB and PAF, associations of AHI and LFP, nadir SaO Conclusions: Autonomic measures exhibited diurnal variation in moderate-severe SDB and were influenced by CPAP. Association with SDB severity was more pronounced during wakefulness, providing key insights into likelihood of sustained chronobiologic electrophysiological remodeling.
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