Evidence map›Paper›PMID 42282011›Full record

ArticleResearch square2026

A reversible broad-spectrum antiviral targets the human V-ATPase V

Jimena Pérez-Vargas, Diana Bautista-Sánchez, Rebecca A Oot, Connor A H Thompson, David E Williams, Lianne Presley, Danielle G Gordon, Annika Lea Schulz, Kassidy Knight, Siobhan Ennis and 21 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Jimena Pérez-VargasUniversity of British Columbia.ORCID 0000-0002-4337-7903
Diana Bautista-SánchezUniversity of British Columbia.
Rebecca A OotState University of New York Upstate Medical University.
Connor A H ThompsonUniversity of British Columbia.
David E WilliamsUniversity of British Columbia.
Lianne PresleyUniversity of British Columbia.
Danielle G GordonUniversity of British Columbia.
Annika Lea SchulzUniversity of British Columbia.
Kassidy KnightState University of New York Upstate Medical University.
Siobhan EnnisSimon Fraser University.ORCID 0000-0002-0105-8269
David ScheibnerFederal Research Institute for Animal Health.
Luka KrampertUniversity of British Columbia.
Steven J McArthurUniversity of British Columbia.ORCID 0009-0005-9034-4329
Nidhi KaushikVaccine and Infectious Disease Organization, University of Saskatchewan.
Syan OlverVaccine and Infectious Disease Organization, University of Saskatchewan.
Guang GaoUniversity of British Columbia.ORCID 0000-0001-7523-2234
Jun Bae ParkSeoul National University.
Ivan VillanuevaUniversity of British Columbia.ORCID 0000-0002-9325-731X
Keryanne GagnonUniversity of British Columbia.
Alexander NowakowskiMcGill University.ORCID 0000-0003-3503-5281
Claire M BrownMcGill University.ORCID 0000-0003-1622-663X
Leon H ChewStemcell Technologies.
Erin KnockStemcell Technologies.
Brian HetrickVirongy Biosciences, Inc.ORCID 0000-0001-6394-8593
Sandra DiederichFederal Research Institute for Animal Health.ORCID 0000-0001-6740-3312
Soung-Hun RohSeoul National University.
Masahiro NiikuraSimon Fraser University.ORCID 0000-0001-6611-8616
Bryce WarnerVaccine and Infectious Disease Organization, University of Saskatchewan.ORCID 0000-0003-2635-5072
Stephan WilkensState University of New York Upstate Medical University.
Raymond J AndersenUniversity of British Columbia.ORCID 0000-0002-7607-8213
François JeanUniversity of British Columbia.ORCID 0000-0002-6148-7460

Funding

Structure and Regulatory Mechanisms of the Vacuolar ATPaseR35GM141908 · NIGMS · UPSTATE MEDICAL UNIVERSITY · PI WILKENS, STEPHAN · 2021 to 2025
$2.1M
A novel tool for organelle and isoform specific targeting of V-ATPase in cancerR21CA228340 · NCI · UPSTATE MEDICAL UNIVERSITY · PI WILKENS, STEPHAN · 2019 to 2020
$388k
NCI NIH HHS R21 CA228340NIGMS NIH HHS R35 GM141908
6 · The paper itself

Abstract

Increasing threats of viral disease underscore the urgent need for broad-spectrum antiviral drugs (BSADs). Host proteins utilized by human pathogenic viruses are key BSAD targets. The vacuolar-type H

Indexed as

broad-spectrum antiviralcladoniamide Ahost-directed antiviralpH-dependent viral entryV-ATPase inhibition

Identifiers

PMID42282011
PMCPMC13252584

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.