Evidence map›Paper›PMID 42282520›Full record

ArticlebioRxiv : the preprint server for biology2026

Eyewire II - A connectomic resource for resolving cell types and circuits of the mouse retina.

Sebastian Ströh, Simone Ebert, Julia Fadjukov, Jan Lause, Jonathan Oesterle, Katrin Franke, Ziwei Huang, Ran Lu, Arie Matsliah, David Berson and 16 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Sebastian StröhPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0000-0001-8128-2617
Simone EbertHertie Institute for Artificial Intelligence in Brain Health, University of Tübingen, Tübingen, Germany.ORCID 0009-0008-9071-4467
Julia FadjukovDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-0530-5183
Jan LauseHertie Institute for Artificial Intelligence in Brain Health, University of Tübingen, Tübingen, Germany.ORCID 0000-0003-0946-412X
Jonathan OesterleHertie Institute for Artificial Intelligence in Brain Health, University of Tübingen, Tübingen, Germany.ORCID 0000-0001-8919-1445
Katrin FrankeInstitute of Ophthalmic Research, University of Tübingen, Tübingen, Germany.ORCID 0000-0002-8649-4835
Ziwei HuangHertie Institute for Artificial Intelligence in Brain Health, University of Tübingen, Tübingen, Germany.ORCID 0000-0001-7517-0395
Ran LuPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Arie MatsliahPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0009-0001-4490-2028
David BersonDepartment of Neuroscience, Brown University, Providence, RI, USA.ORCID 0000-0002-3827-0079
Venus SherathiyaDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Dominic GonschorekInstitute of Ophthalmic Research, University of Tübingen, Tübingen, Germany.ORCID 0000-0001-5118-9817
Timm SchubertInstitute of Ophthalmic Research, University of Tübingen, Tübingen, Germany.
Celia DavidPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0009-0000-0149-7555
Marissa SorekPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0009-0008-7636-0746
Amy SterlingPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-4961-3954
Nikitas SerafetinidisEyewire Citizen Scientist Community.
Joshua SingerDepartment of Biology, University of Maryland, College Park, MD, USA.ORCID 0000-0002-0561-2247
Yoshihiko TsukamotoDepartment of Biology, Hyogo Medical University, Mukogawa, Nishinomiya, Hyogo, Japan.ORCID 0009-0001-2560-7832
Hiromi MaeyamaStudio EM-Retina, Satonaka, Nishinomiya, Hyogo, Japan.
Naoko OmiStudio EM-Retina, Satonaka, Nishinomiya, Hyogo, Japan.
Gregory SchwartzDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-8909-4397
Philipp BerensHertie Institute for Artificial Intelligence in Brain Health, University of Tübingen, Tübingen, Germany.ORCID 0000-0002-0199-4727
H Sebastian SeungPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-8591-6733
Thomas EulerInstitute of Ophthalmic Research, University of Tübingen, Tübingen, Germany.ORCID 0000-0002-4567-6966
Eyewire II Consortium

Funding

Circuit Mechanisms Underlying Persistent Activity in a Neural IntegratorR01EY027036 · NEI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Emre R Aksay, MARK S GOLDMAN · 2016 to 2026
$6.4M
Circuit Mechanisms Underlying Learned Changes in Persistent Neural ActivityR01NS104926 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI AKSAY, EMRE R, GOLDMAN, MARK S · 2018 to 2022
$4.1M
Vertically integrated approach to visual neuroscience: microcircuits to behaviorU01NS090562 · NINDS · PRINCETON UNIVERSITY · PI EULER, THOMAS, HUBERMAN, ANDREW D · 2014 to 2016
$3.6M
Multimodal classification and sub-cellular compartmentalization of displaced amacrine cells in the mouse retinaR01EY036978 · NEI · NORTHWESTERN UNIVERSITY · PI Gregory William Schwartz · 2025 to 2026
$1.1M
Retinal connectome: mobile game and crowdsourcing algorithms for EyeWire IIUH2CA203710 · NCI · PRINCETON UNIVERSITY · PI SEUNG, HYUNJUNE SEBASTIAN · 2016 to 2017
$642k
NCI NIH HHS UH2 CA203710NEI NIH HHS R01 EY027036NEI NIH HHS R01 EY036978NINDS NIH HHS R01 NS104926NINDS NIH HHS U01 NS090562
6 · The paper itself

Abstract

Comprehensive wiring diagrams from electron microscopy (EM) are a powerful tool to understand the inner workings of the brain. The retina is an easily accessible part of the brain that performs complex visual computations. Its thin, layered structure offers a unique opportunity to decipher neural cell types and map their connectivity. A major obstacle has been the limited size of existing retinal EM datasets, which could not resolve rare cell types and neurons with large dendritic arbors. Here, we describe Eyewire II, a large-scale EM dataset covering nearly 1 mm

Indexed as

calcium imagingcommunity resourceconnectomeelectron microscopymachine learningmorphological cell typingmouseretina

Identifiers

PMID42282520
PMCPMC13252113

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.