ArticlebioRxiv : the preprint server for biology2026
Fetal MRI reveals altered prenatal cortical surface area in fetuses later diagnosed with autism spectrum disorder.
Andrea Gondova, Suzette Saucedo Olvera, Yinong Qiu, Haiyi Guo, Seungyoon Jeong, Wendy K Chung, P Ellen Grant, Xue-Jun Kong, Kiho Im
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Andrea GondovaFetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.ORCID 0000-0001-7442-5747 Suzette Saucedo OlveraFetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Yinong QiuFetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Haiyi GuoFetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Seungyoon JeongFetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Wendy K ChungDepartment of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.ORCID 0000-0003-3438-5685 P Ellen GrantFetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.ORCID 0000-0003-1005-4013 Xue-Jun KongFetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.ORCID 0000-0001-8551-8877 Kiho ImFetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.ORCID 0000-0002-9239-8970 Funding
Genetic and Hemodynamic Effects on Prenatal Cortical Development in Congenital Heart DiseaseR01NS114087 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI IM, KIHO · 2020 to 2024
$2.8MMeasuring cortical plate and subplate thickness in the human fetal brain from magnetic resonance imagesR01EB031170 · NIBIB · BOSTON CHILDREN'S HOSPITAL · PI IM, KIHO · 2021 to 2025
$2.5MFetal Brain MRI as a Predictor of Late Neurodevelopmental Outcome in Congenital Heart DiseaseR01NS121334 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI Caitlin Rollins · 2022 to 2026
$2.2MFetal Brain Development in Congenital Heart DiseaseK23NS101120 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI ROLLINS, CAITLIN · 2017 to 2022
$1.1MNIBIB NIH HHS R01 EB031170NINDS NIH HHS K23 NS101120NINDS NIH HHS R01 NS114087NINDS NIH HHS R01 NS121334
6 · The paper itselfAbstract
Autism spectrum disorder (ASD) is increasingly conceptualized as a condition rooted in altered prenatal neurodevelopment, yet in vivo evidence from fetal brain imaging remains limited. Using retrospective fetal MRI and surface-based morphometry, we investigated cortical development in 15 fetuses later diagnosed with ASD (77%; mean gestational age [GA] = 26.7 weeks) without major structural brain abnormalities and compared them with 60 typically developing controls (57% male; mean GA = 28.4 weeks). Fetuses later diagnosed with ASD showed significantly reduced whole-brain inner cortical plate surface area compared with controls (β = -0.08 ± 0.02 SE, p = 0.002, partial η
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PMID42282553
PMCPMC13252390
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