Evidence map›Paper›PMID 42282628›Full record

ArticlebioRxiv : the preprint server for biology2026

Human hip osteoarthritis-associated

Kimheak Sao, Bryn Mallon, Jacqueline Shine, Anastasia Mavridis, Elena V Filippova, Jack R Felkner, Carson D Shepler, Tanner M Orders, Susan D'Costa, William A Cowan and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kimheak SaoDepartment of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, USA.
Bryn MallonDepartment of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, USA.
Jacqueline ShineThurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Anastasia MavridisDepartment of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, USA.
Elena V FilippovaThurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Jack R FelknerThurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Carson D SheplerThurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Tanner M OrdersDepartment of Orthopaedics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Susan D'CostaThurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
William A CowanThurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Brian O DiekmanThurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Makarand V RisbudDepartment of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, USA.

Funding

Targeting cell senescence in a novel model of spontaneous disc degenerationR01AG073349 · NIA · THOMAS JEFFERSON UNIVERSITY · PI RISBUD, MAKARAND V · 2021 to 2025
$3.0M
The role of endogenous low molecular weight mineralization inhibitors in spine healthR01AR082460 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI Makarand V Risbud, Koen van de Wetering · 2024 to 2026
$1.9M
Functional interrogation of putative osteoarthritis causal variantsR21AR084104 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DIEKMAN, BRIAN O · 2024 to 2025
$371k
Role of HIF-1 in intervertebral disc functionR56AR055655 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI RISBUD, MAKARAND V · 2024 to 2024
$312k
NIAMS NIH HHS R01 AR082460NIAMS NIH HHS R21 AR084104NIAMS NIH HHS R56 AR055655NIA NIH HHS R01 AG073349
6 · The paper itself

Abstract

Chondroadherin-like (CHADL), a small leucine-rich proteoglycan, plays a role in ECM assembly and chondrocyte differentiation. CHADL has been implicated in osteoarthritis (OA) due to the discovery of a rare frameshift variant (rs532464664) that confers one of the highest genetic risks for hip OA reported to date. In this study, we characterized the skeletal phenotypes of two mouse models of

Identifiers

PMID42282628
PMCPMC13251957

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.