Evidence map›Paper›PMID 42282640›Full record

ArticlebioRxiv : the preprint server for biology2026

A Human Vocal Fold Organ-On-Chip for Studying Platform-Dependent Mucosal Responses to Particulate Matter.

Patrick T Coburn, Meghana Munipalle, Yin Liu, Vlasta Lungova, Samjhana Thapa, Lisa Martignetti, Xinyu Liu, Gilles Maussion, Carol X-Q Chen, Thomas M Durcan and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Patrick T CoburnSchool of Communication Sciences and Disorders, McGill University, Montreal, Canada.
Meghana MunipalleDepartment of Biomedical Engineering, McGill University, Montreal, Canada.
Yin LiuDepartment of Biomedical Engineering, McGill University, Montreal, Canada.
Vlasta LungovaDepartment of Otolaryngology - Head and Neck Surgery, University of Wisconsin-Madison, Wisconsin, USA.
Samjhana ThapaDepartment of Biomedical Engineering, McGill University, Montreal, Canada.
Lisa MartignettiSchool of Communication Sciences and Disorders, McGill University, Montreal, Canada.
Xinyu LiuDepartment of Mechanical Engineering, University of Toronto, Toronto, Canada.
Gilles MaussionEarly Drug Discovery Unit, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.
Carol X-Q ChenEarly Drug Discovery Unit, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.
Thomas M DurcanEarly Drug Discovery Unit, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.
Susan L ThibeaultDepartment of Otolaryngology - Head and Neck Surgery, University of Wisconsin-Madison, Wisconsin, USA.
Nicole Y K Li-JessenSchool of Communication Sciences and Disorders, McGill University, Montreal, Canada.ORCID 0000-0003-2963-4763

Funding

Engineering the Vocal Fold MucosaR01DC004336 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI Susan Lynn Thibeault · 2000 to 2026
$14.6M
Bioprintable composite materials and microfluidic tools for vocal fold restoration and repairR01DC018577 · NIDCD · MCGILL UNIVERSITY · PI MONGEAU, LUC · 2021 to 2025
$2.5M
NIDCD NIH HHS R01 DC004336NIDCD NIH HHS R01 DC018577
6 · The paper itself

Abstract

Background: Coarse particulate matter (PM Methods: Vocal fold organ-on-chip (VF-OOC) paired primary VF fibroblasts with either immortalized laryngeal epithelial cells (iLEC) or induced pluripotent stem cells (iPSC)-derived VF epithelial cells. Transwell and 2D chip cultures were controls. Epithelia matured at an air-liquid interface on fibroblast-embedded collagen over a perfused microchannel. PM Results: VF-OOC produced a thicker stratified epithelium with upregulated barrier, mucin, and extracellular matrix genes versus transwell controls. Intercellular junctions and basement membrane matched adult human VF mucosa. PM Conclusions: VF-OOC reproduced key features of native human VF mucosa and captured distinct, platform-specific responses to PM

Indexed as

Microfluidic ModelsParticulate MatterPollutant ToxicityUpper Airway HealthVocal Folds

Identifiers

PMID42282640
PMCPMC13252023

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.