ReviewMacromolecular rapid communications2026
Adaptive Hyaluronic Acid Hydrogels for Regenerative Wound Healing: From Microenvironment Sensing to ECM Reprogramming and Precise Tissue Regeneration.
Review in Macromolecular rapid communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impaired wound healing is primarily influenced by oxidative stress, aberrant enzyme activity, and disruption of the extracellular matrix (ECM), conditions that conventional dressings inadequately address. In contrast, adaptive hyaluronic acid (HA) hydrogels have emerged as a promising platform due to their inherent bioactivity and structural tunability. This review elucidates recent advancements in stimulus-responsive HA hydrogels, with a particular emphasis on the translation of pH, reactive oxygen species (ROS), enzymatic activity, and mechanical stimuli into network remodeling and controlled therapeutic release. Exemplary systems, such as Schiff base-based pH-responsive hydrogels, disulfide-crosslinked ROS-responsive platforms, and matrices sensitive to matrix metalloproteinases (MMPs), illustrate how structure-function relationships facilitate precise regulation of inflammation, angiogenesis, and tissue repair. Furthermore, we explore how these materials orchestrate biochemical signaling, matrix mechanics, and dynamic structural adaptation to influence ECM remodeling and cellular behavior. Finally, we outline emerging strategies, including spatiotemporal regulation, multi-signal integration, and AI-assisted design, to address existing challenges in predictability and clinical translation. This review provides a design-oriented perspective for developing next-generation adaptive hydrogels for precise regenerative medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.