Evidence map›Paper›PMID 42283631›Full record

ArticleApplied and environmental microbiology2026

Xylose-induced tricarboxylic acid cycle activation resensitizes gentamicin-resistant

Ling Chen, Sufang Kuang, Chenyu Bao, Wenjing Fu, Siying Lin, Tao Yuan

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ling Chen *Jiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research, College of Pharmacy, Jiangxi Normal University, Nanchang, China.ORCID 0009-0003-2564-3483
Sufang Kuang *Jiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research, College of Pharmacy, Jiangxi Normal University, Nanchang, China.ORCID 0009-0009-4527-077X
Chenyu BaoCollege of Life Sciences, Jiangxi Normal University, Nanchang, China.
Wenjing FuJiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research, College of Pharmacy, Jiangxi Normal University, Nanchang, China.
Siying LinJiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research, College of Pharmacy, Jiangxi Normal University, Nanchang, China.
Tao YuanJiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research, College of Pharmacy, Jiangxi Normal University, Nanchang, China.ORCID 0000-0001-7746-3714

Funding

Graduate Innovation Fund Project of the Jiangxi Province Department of Education YC2024-S272Jiangxi Normal University Doctoral Research Fund 12022819Jiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research Fund 2024SSY07051National Natural Science Foundation of China 22207050National Natural Science Foundation of China 22477048Natural Science Foundation of Jiangxi Province 20252BAC200362
6 · The paper itself

Abstract

The escalating antibiotic resistance crisis requires innovative strategies to revitalize existing antibiotics. Here, we report that xylose, a food-grade sugar poorly metabolized by humans but readily utilized by bacteria, acts as a potent metabolic adjuvant to restore gentamicin efficacy against bacteria. Using a laboratory-evolved gentamicin-resistant

Indexed as

Anti-Bacterial AgentsCitric Acid CycleDrug Resistance, BacterialEscherichia coliGentamicinsXyloseAnimalsEscherichia coli InfectionsMiceAnti-Bacterial AgentsGentamicinsXyloseEscherichia coligentamicinreactivatingTCA cyclexylose

Identifiers

PMID42283631
PMCPMC13390390

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.