Evidence map›Paper›PMID 42283775›Full record

ArticleGeroScience2026

Using kidney transplantation to explore epigenetic markers of frailty.

Y Yang, F Giddens, S Neupane, L Tran, R Tannenberg, N Reid, R E Hubbard, A Shaw, R S Francis, J Gratten and 1 more

Abstract read
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In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Y YangMater Research Institute, The University of Queensland, Brisbane, Australia.
F GiddensKidney and Transplant Services, Princess Alexandra Hospital, Brisbane, Australia.
S NeupaneMater Research Institute, The University of Queensland, Brisbane, Australia.
L TranMater Research Institute, The University of Queensland, Brisbane, Australia.
R TannenbergMater Research Institute, The University of Queensland, Brisbane, Australia.
N ReidCentre for Health Services Research, The University of Queensland, Brisbane, Australia.
R E HubbardCentre for Health Services Research, The University of Queensland, Brisbane, Australia.
A ShawCentre for Health Services Research, The University of Queensland, Brisbane, Australia.
R S FrancisKidney and Transplant Services, Princess Alexandra Hospital, Brisbane, Australia.
J GrattenMater Research Institute, The University of Queensland, Brisbane, Australia.
E H GordonCentre for Health Services Research, The University of Queensland, Brisbane, Australia. e.gordon@uq.edu.au.

Funding

Metro South Health Research Support Scheme RSS_2022_117
6 · The paper itself

Abstract

The aetiology of frailty remains unknown. It has been hypothesised that individual differences in epigenetic mechanisms, particularly DNA methylation (DNAm), may help to explain why some individuals become frail while others do not. Relating epigenetic measures to transitions in age-related frailty in individual patients requires longitudinal studies over many years. To overcome this barrier, we study associations between DNAm and the Frailty Index in a cohort of adults with kidney failure who experience accelerated transitions of frailty with and without kidney transplantation. While transplantation was associated with reduced frailty, there was minimal evidence for an association between frailty and epigenetic markers.

Indexed as

DNA methylationEpigeneticsFrailty IndexKidney failure

Identifiers

PMID42283775

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.