ReviewStem cell reviews and reports2026
Stem Cell and Stem Cell-Derived Extracellular Vesicles: Therapeutic Potential and Mechanistic Insights in Anti-Aging.
Review in Stem cell reviews and reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Aging is driven by interconnected molecular and cellular processes (senescence, inflammation, proteostasis decline, mitochondrial dysfunction) that reduce tissue repair and organismal resilience, resulting in an increased prevalence of chronic degenerative conditions. Accordingly, the development of strategies to prevent, delay, or mitigate multiple age-related diseases is imperative. Embryonic stem cells (ESCs) and other pluripotent stem cells (PSCs) offer substantial therapeutic potential owing to their self-renewal and cellular plasticity, but their direct clinical use is limited by concerns of immunogenicity, tumorigenicity, and ethical constraints. ESC- and PSC-derived extracellular vesicles (ESC-EVs/PSC-EVs) have emerged as promising alternatives that may capture many of the regenerative and modulatory benefits of their parent cells while reducing associated risks. Cumulative evidence shows that EVs from young or stem-like cells mainly produce rejuvenating effects across tissues and molecular pathways. Here we summarize key biological features of stem cells and their EVs, outline mechanisms by which EVs impact aging hallmarks, and assess preclinical and early clinical findings on stem cell and EVs interventions for aging and age-related diseases. Careful optimization of EVs production, standardized characterization, and thorough safety and efficacy testing in diverse disease models and clinical contexts are essential to translate PSC-EVs approaches into viable therapies.
Indexed as
Identifiers
42284014What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.