ArticleCell reports2026
Fgf18 marks reserve skeletal progenitors in the fibrous periosteum contributing to bone fracture repair.
Xing Ji, Jasmin Koehnken Sawall, Xuejun Zhang, David M Ornitz, Fanxin Long
Abstract read
In one paragraphArticle in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
5 authors.
Xing JiTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Institute of Orthopedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China.
Jasmin Koehnken SawallTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Xuejun ZhangTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
David M OrnitzDepartment of Developmental Biology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Fanxin LongTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Orthopedic Surgery, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: longf1@chop.edu.
Funding
Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8MRegulation of Osteocyte Survival by Fibroblast Growth Factor Signaling PathwaysR01AR079246 · NIAMS · WASHINGTON UNIVERSITY · PI David M Ornitz · 2022 to 2026
$2.5MIlluminating adipo-osteoprogenitors in the bone marrowR01AG077911 · NIA · CHILDREN'S HOSP OF PHILADELPHIA · PI Fanxin Long · 2023 to 2026
$1.8MThe cell metabolism basis for bone complications in type I diabetesR01DK125498 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI LONG, FANXIN · 2021 to 2024
$1.8MIdentification of an FGF-regulated signaling center in the Groove of Ranvier that controls longitudinal bone growth.R21AR082001 · NIAMS · WASHINGTON UNIVERSITY · PI ORNITZ, DAVID M · 2023 to 2024
$371kNIAMS NIH HHS P30 AR074992NIAMS NIH HHS R01 AR079246NIAMS NIH HHS R21 AR082001NIA NIH HHS R01 AG077911NIDDK NIH HHS R01 DK125498
6 · The paper itselfAbstract
The periosteum, a thin membranous tissue covering the external bone surface, is a well-established source of osteogenic activity during bone growth and fracture repair. However, the molecular identity and anatomical niche of its progenitor cells remain incompletely defined. Using single-cell RNA sequencing and RNA in situ hybridization in mouse long bones, we identified that fibroblast growth factor 18 (Fgf18) expression marks a discrete subset of cells within the fibrous layer of the periosteum that co-express genes associated with skeletal stem and progenitor populations. Lineage tracing revealed that Fgf18
Indexed as
Fibroblast Growth FactorsFracture HealingFractures, BonePeriosteumStem CellsAnimalsCell LineageChondrocytesMiceOsteoblastsOsteogenesisfibroblast growth factor 18Fibroblast Growth FactorsboneCP: developmental biologyCP: stem cell researchFgf18fracture repairlineage tracingmouseperiosteumreserve skeletal progenitors
Identifiers
PMID42284141
PMCPMC13359388
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