ArticleScience advances2026
SUCNR1 coordinates metabolic flux, mitochondrial function, and nutrient-dependent adaptation in hepatocytes.
Anna Marsal-Beltran, Laura Salmerón-Pelado, Aleix Ribas-Latre, Maria Repollés-de-Dalmau, M-Mar Rodríguez-Peña, Catalina Núñez-Roa, Joan Badia, Ana Madeira, Eva Novoa, Marc Beltrà and 11 more
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In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
21 authors.
Anna Marsal-BeltranInstitut de Recerca Biomèdica Catalunya Sud (formerly Institut d'Investigació Sanitària Pere Virgili), Hospital Universitari Joan XXIII, Tarragona 43005, Spain.ORCID 0000-0001-9521-6522 Laura Salmerón-PeladoInstitut de Recerca Biomèdica Catalunya Sud (formerly Institut d'Investigació Sanitària Pere Virgili), Hospital Universitari Joan XXIII, Tarragona 43005, Spain.ORCID 0009-0005-2895-4601 Aleix Ribas-LatreInstitut de Recerca Biomèdica Catalunya Sud (formerly Institut d'Investigació Sanitària Pere Virgili), Hospital Universitari Joan XXIII, Tarragona 43005, Spain.
Maria Repollés-de-DalmauInstitut de Recerca Biomèdica Catalunya Sud (formerly Institut d'Investigació Sanitària Pere Virgili), Hospital Universitari Joan XXIII, Tarragona 43005, Spain.ORCID 0000-0003-1402-0611 M-Mar Rodríguez-PeñaInstitut de Recerca Biomèdica Catalunya Sud (formerly Institut d'Investigació Sanitària Pere Virgili), Hospital Universitari Joan XXIII, Tarragona 43005, Spain.
Catalina Núñez-RoaInstitut de Recerca Biomèdica Catalunya Sud (formerly Institut d'Investigació Sanitària Pere Virgili), Hospital Universitari Joan XXIII, Tarragona 43005, Spain.ORCID 0000-0003-2764-5610 Joan BadiaPlataformes de Bioinformàtica i de Suport Estadístic, Institut de Recerca Biomèdica Catalunya Sud-CERCA, Tarragona 43005, Spain.ORCID 0000-0001-7446-7365 Ana MadeiraInstitut de Recerca Biomèdica Catalunya Sud (formerly Institut d'Investigació Sanitària Pere Virgili), Hospital Universitari Joan XXIII, Tarragona 43005, Spain.ORCID 0000-0003-3186-359X Eva NovoaDepartment of Physiology, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, Santiago de Compostela 15782, Spain.ORCID 0000-0002-6708-5382 Marc BeltràCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid 28029, Spain.ORCID 0000-0001-6070-9861 Ana Belén Plata-GómezMetabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.ORCID 0000-0002-6256-0084 Jordi CapelladesInstitut de Recerca Biomèdica Catalunya Sud (formerly Institut d'Investigació Sanitària Pere Virgili), Hospital Universitari Joan XXIII, Tarragona 43005, Spain.ORCID 0000-0002-6502-8202 Joan Carles Escolà-GilCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid 28029, Spain.ORCID 0000-0001-9021-2485 Antonio ZorzanoCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid 28029, Spain.ORCID 0000-0002-1638-0306 Óscar YanesCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid 28029, Spain.ORCID 0000-0003-3695-7157 Alejo EfeyanMetabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.ORCID 0000-0002-3806-6799 Ruben NogueirasDepartment of Physiology, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, Santiago de Compostela 15782, Spain.ORCID 0000-0002-9976-9930 Jordi Gracia-SanchoBiomedical Research Network on Hepatic and Digestive Diseases (CIBEREHD), Instituto de Salud Carlos III, Madrid 28029, Spain.ORCID 0000-0001-7736-4089 Joan VendrellInstitut de Recerca Biomèdica Catalunya Sud (formerly Institut d'Investigació Sanitària Pere Virgili), Hospital Universitari Joan XXIII, Tarragona 43005, Spain.ORCID 0000-0002-6994-6115 Victòria Ceperuelo-MallafréInstitut de Recerca Biomèdica Catalunya Sud (formerly Institut d'Investigació Sanitària Pere Virgili), Hospital Universitari Joan XXIII, Tarragona 43005, Spain.ORCID 0000-0002-4460-9761 Sonia Fernández-VeledoInstitut de Recerca Biomèdica Catalunya Sud (formerly Institut d'Investigació Sanitària Pere Virgili), Hospital Universitari Joan XXIII, Tarragona 43005, Spain.ORCID 0000-0003-2906-3788 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Succinate, a mitochondrial metabolite, also functions as an extracellular signal through its receptor succinate receptor 1 (SUCNR1), coordinating responses to nutrient availability. The physiological role of SUCNR1 within hepatocytes, however, is unclear. We show that hepatic succinate levels and
Indexed as
HepatocytesMitochondriaNutrientsReceptors, G-Protein-CoupledAdaptation, PhysiologicalAnimalsCitric Acid CycleGluconeogenesisGlucoseLiverMetabolic ReprogrammingMiceMice, KnockoutSignal TransductionSuccinic AcidGlucoseGPR91 protein, mouseReceptors, G-Protein-CoupledSuccinic Acid
Identifiers
PMID42284407
PMCPMC13262611
What Socratic holds
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