ArticleScience advances2026
Oxytocin attenuates fear learning via enhancing somatostatin interneuron-mediated local GABAergic inhibition in the prelimbic cortex.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Dysregulation of local inhibitory inputs onto laterodorsal tegmental nucleus cholinergic neurons drives depression-like behaviors in mice.Molecular psychiatry · 2026Article
- Hypothalamic oxytocin neurons produce pro-anxiety effects through glutamatergic projections to the lateral hypothalamus.Cell discovery · 2026Article
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Authors and funding
8 authors.
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Abstract
Acute stress exposure can trigger post-traumatic stress disorder (PTSD). Prophylactic interventions may enhance psychological resilience against PTSD in high-risk occupations. Here, we demonstrate that pretreating with intranasal oxytocin exerts prolonged yet reversible attenuation of fear learning via oxytocin receptors (OxtRs) expressed in prelimbic cortex (PL). Crucially, both local PL oxytocin infusion and selective activation of PL OxtR+ neurons recapitulate this fear reduction. Although OxtRs are expressed on pyramidal and somatostatin (SST) neurons, SST interneurons exhibit higher
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