ArticleImmunity2026
A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains a homeostatic Th17 cell state.
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Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
24 authors.
Dandan YangGene Lay Institute of Immunology and Inflammation, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02149, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA.
Linglin HuangGene Lay Institute of Immunology and Inflammation, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02149, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA.
Hanning ChengGene Lay Institute of Immunology and Inflammation, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02149, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA.
Nandini AcharyaGene Lay Institute of Immunology and Inflammation, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02149, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA; Department of Neurology, The Neuroscience Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Davide ManganiGene Lay Institute of Immunology and Inflammation, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02149, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA.
Yong HuAnn Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA.
Dan HuAnn Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA.
Alissa J NelsonCell Signaling Technology, Danvers, MA 01923, USA.
Jian Min RenCell Signaling Technology, Danvers, MA 01923, USA.
Vicky YangCell Signaling Technology, Danvers, MA 01923, USA.
Junrong XiaGene Lay Institute of Immunology and Inflammation, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02149, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA.
Linfeng LeGene Lay Institute of Immunology and Inflammation, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02149, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA.
Yifan CaiGene Lay Institute of Immunology and Inflammation, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02149, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA.
Yufan WuGene Lay Institute of Immunology and Inflammation, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02149, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA.
Alexandra SchnellGene Lay Institute of Immunology and Inflammation, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02149, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA.
Rajesh K KrishnanAnn Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA.
Shrishti SaxenaAnn Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA.
Mariann Polgar-TurcsanyiAnn Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA.
Tanuja ChitnisAnn Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA.
Matthew P StokesCell Signaling Technology, Danvers, MA 01923, USA.
Clare M Baecher-AllanAnn Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA.
Raymond A SobelDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Vijay K KuchrooGene Lay Institute of Immunology and Inflammation, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02149, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA.
Ana C AndersonGene Lay Institute of Immunology and Inflammation, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02149, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Mass General Brigham, Boston, MA 02115, USA. Electronic address: acanderson@bwh.harvard.edu.
Funding
Metabolic regulators of Treg/Th17 balance in CNS autoimmunityR01AI169075 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI VIJAY K. KUCHROO · 2022 to 2026
$2.8MA TCF1:Glucocorticoid regulatory circuit controls IL-23-driven Th17 pathogenicityR01AI176341 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI ANA C ANDERSON · 2023 to 2026
$2.1MNIAID NIH HHS R01 AI169075NIAID NIH HHS R01 AI176341
Abstract
T helper 17 (Th17) cells are heterogeneous: homeostatic Th17 (Th17
Indexed as
GlucocorticoidsHomeostasisTh17 CellsAnimalsCell DifferentiationCholesterol Side-Chain Cleavage EnzymeMiceMice, Inbred C57BLMice, KnockoutReceptors, GlucocorticoidSignal TransductionTransforming Growth Factor beta1Cholesterol Side-Chain Cleavage EnzymeGlucocorticoidsReceptors, GlucocorticoidTransforming Growth Factor beta1CNS autoimmunityCYP11A1glucocorticoidhomeostasisNrc31steroid resistanceTGF-β1Th17
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.