Evidence map›Paper›PMID 42285772›Full record

ArticleExperimental physiology2026

Acute capillary blood DNA methylation responses to swimming exercise in high-performance male and female swimmers.

C D Goldsmith, N G Lawler, D B Pyne, M Kozlovskaia, K McGibbon, L J G Mitchell, A D Govus

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

C D GoldsmithTranslational Health Research Institute, Western Sydney University, Parramatta, New South Wales, Australia.
N G LawlerAustralian National Phenome Centre, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0001-9649-425X
D B PyneResearch Institute Sport and Exercise, University of Canberra, Canberra, Australia.ORCID https://orcid.org/0000-0003-1555-5079
M KozlovskaiaResearch Institute Sport and Exercise, University of Canberra, Canberra, Australia.
K McGibbonPerformance Science Unit, Queensland Academy of Sport, Nathan, Queensland, Australia.
L J G MitchellVictorian Institute of Sport, Albert Park, Victoria, Australia.
A D GovusDiscipline of Sport and Exercise Science, La Trobe University, Bundoora, Victoria, Australia.ORCID https://orcid.org/0000-0001-6224-0454

Funding

La Trobe UniversityQueensland Academy of Sport Innovation and Knowledge Excellence (SPIKE)University of CanberraUniversity of Canberra Research Institute for Sport and Exercise
6 · The paper itself

Abstract

Epigenetic markers, particularly DNA methylation, are promising tools for monitoring athlete health and training due to their role in cellular regulation, exercise responsiveness and molecular stability. However, exercise-induced epigenetic changes in peripheral blood in trained individuals remain unexplored. Therefore, we investigated the whole blood DNA methylation responses to swimming performed in the moderate (below critical speed) and severe (above critical speed) intensity domains using minimally invasive sampling. Ten high-performance swimmers (5 males, 5 females; age 16-24 years) completed a 12 × 25 m maximal effort trial to determine critical swimming speed. One week later, participants performed two separate trials in the moderate and severe domains. Capillary blood (1 mL) was collected pre- and post-exercise for DNA methylation profiling via reduced representation bisulfite sequencing. Global methylation and differentially methylated loci (DMLs) and regions (DMRs) were assessed using logistic regression. Exercise induced global hypomethylation regardless of intensity (severe domain: 0.25% difference; 95% CI: 0.023, 0.372; P

Indexed as

CapillariesDNA MethylationExerciseSwimmingAdolescentAthletesEpigenesis, GeneticFemaleHumansMaleYoung Adult5mCbiomarkersepigeneticsphenotypeRRBSsport

Identifiers

PMID42285772
PMCPMC13394561

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.