Evidence map›Paper›PMID 42285890›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2026

Preselection CD4+CD8+ thymocytes modulate TCR responsiveness following TCRβ selection.

Esther Jeong Yoon Kim, Dominik A Aylard, Zoë Steier, Daisy Ortiz, Jean Choi, Stefanie Chen, Aaron Streets, Nir Yosef, Ellen A Robey

Abstract read
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In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Esther Jeong Yoon KimDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States.
Dominik A AylardDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States.
Zoë SteierInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States.
Daisy OrtizDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States.
Jean ChoiDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States.
Stefanie ChenDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States.
Aaron StreetsDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA, United States.
Nir YosefDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
Ellen A RobeyDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States.ORCID 0000-0002-3630-5266

Funding

Signals That Control Thymocyte MigrationR01AI064227 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI ELLEN A ROBEY · 2006 to 2026
$7.4M
National Institute of Allergy and Infectious Diseases of the National Institutes of Health AI064227National Institute of Allergy and Infectious Diseases of the National Institutes of Health AI145816NIAID NIH HHS R01 AI064227
6 · The paper itself

Abstract

Modulation of T cell receptor (TCR) sensitivity during positive selection is critical to avoid negative selection and direct thymocytes into their appropriate lineage. Thymocytes just prior to positive selection (preselection) are highly responsive to low affinity self-ligands and are also actively rearranging their TCRα locus as they await a positive selection signal. Preselection double-positive thymocytes were thought to be relatively homogeneous, and TCR modulation during this stage had not been previously described. Here, we provide evidence for progressive gene expression changes within the preselection double-positive thymocyte population that correlates with a gradual reduction in TCR responsiveness and reduced upregulation of TCR target genes associated with the CD4 fate. We relate these observations to the link between positive selection and T cell lineage commitment.

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesReceptors, Antigen, T-Cell, alpha-betaThymocytesAnimalsCell DifferentiationCell LineageClonal Selection, Antigen-MediatedMiceSignal TransductionReceptors, Antigen, T-Cell, alpha-betacell differentiationsignal transductionsingle-cell sequencingT cellsthymus

Identifiers

PMID42285890

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.