ArticleScientific reports2026
Association between oxidative balance score and psychological disorders in adults.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Maintaining a favorable balance between antioxidants and pro-oxidants, rather than merely increasing antioxidant intake, may be critical for mental health. This study examined the association between Oxidative Balance Score (OBS), an integrated measure of both antioxidant and pro-oxidant exposures, and odds of psychological disorders. This cross-sectional analysis used baseline data from the Isfahan Functional Disorders (ISFUN) cohort. Dietary intakes were assessed using a self-administered, Willett-format, Dish-based, 106-item Semi-quantitative Food Frequency Questionnaire (DS-FFQ). OBS was calculated based on 16 dietary and 4 lifestyle factors. Depression and anxiety symptoms were evaluated using the Iranian-validated Hospital Anxiety and Depression Scale (HADS). After adjusting for confounding variables, higher OBS was significantly associated with reduced odds of depression (OR: 0.65; 95% CI: 0.49-0.86) and anxiety (OR: 0.70; 95% CI: 0.53-0.92). In sex-stratified analyses, a significant inverse association was found between OBS with depression (OR: 0.65; 95% CI: 0.45-0.93) and anxiety (OR: 0.64; 95% CI: 0.45-0.91) among women. However, there was no significant association between OBS with depression and anxiety among men. In conclusion, a higher OBS was associated with reduced odds of depression and anxiety in this population, with this inverse association being statistically significant only in women, highlighting the potential importance of a balanced antioxidant-pro-oxidant profile for mental health. Prospective studies are needed to confirm these findings.
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