Evidence map›Paper›PMID 42286691›Full record

ArticleParticle and fibre toxicology2026

Inhalation exposure to surrogate military burn pit emissions impairs systemic microvascular function: linking pulmonary insult and diverse peripheral responses.

Van Nguyen, Anand Ranpara, William T Goldsmith, Thomas P Batchelor, Jacob Hoyer, Howard D Leonard, Atefeh Razazan, Sara E Lewis, Jacob Krafcheck, Robert Burns and 10 more

Abstract read
In one paragraph

Article in Particle and fibre toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Van NguyenCenter for Inhalation Toxicology (iTOX), West Virginia University, School of Medicine, Morgantown, WV, USA.
Anand RanparaCenter for Inhalation Toxicology (iTOX), West Virginia University, School of Medicine, Morgantown, WV, USA.
William T GoldsmithCenter for Inhalation Toxicology (iTOX), West Virginia University, School of Medicine, Morgantown, WV, USA.
Thomas P BatchelorCenter for Inhalation Toxicology (iTOX), West Virginia University, School of Medicine, Morgantown, WV, USA.
Jacob HoyerCenter for Inhalation Toxicology (iTOX), West Virginia University, School of Medicine, Morgantown, WV, USA.
Howard D LeonardCenter for Inhalation Toxicology (iTOX), West Virginia University, School of Medicine, Morgantown, WV, USA.
Atefeh RazazanCenter for Inhalation Toxicology (iTOX), West Virginia University, School of Medicine, Morgantown, WV, USA.
Sara E LewisCenter for Inhalation Toxicology (iTOX), West Virginia University, School of Medicine, Morgantown, WV, USA.
Jacob KrafcheckCenter for Inhalation Toxicology (iTOX), West Virginia University, School of Medicine, Morgantown, WV, USA.
Robert BurnsSchool of Natural Resources and the Environment, Division of Land Grant Engagement, West Virginia University, Morgantown, WV, USA.
Randy J NelsonDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, School of Medicine, Morgantown, WV, USA.
Pallavi SharmaDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, School of Medicine, Morgantown, WV, USA.
James C WaltonDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, School of Medicine, Morgantown, WV, USA.
Neeharika BeruDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
William BainDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Charles Dela CruzDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Mark WilsonUL Research Institutes' Chemical Insights, Marietta, GA, USA.
Eric E KelleyCenter for Inhalation Toxicology (iTOX), West Virginia University, School of Medicine, Morgantown, WV, USA.
Salik HussainCenter for Inhalation Toxicology (iTOX), West Virginia University, School of Medicine, Morgantown, WV, USA.
Timothy R NurkiewiczCenter for Inhalation Toxicology (iTOX), West Virginia University, School of Medicine, Morgantown, WV, USA. tnurkiewicz@hsc.wvu.edu.

Funding

WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI Trupti Joshi · 2012 to 2026
$61.1M
Inflammatory cross-talk between heat events and air pollutionR01ES031253 · NIEHS · WEST VIRGINIA UNIVERSITY · PI HUSSAIN, SALIK · 2020 to 2024
$3.5M
Pre-doctoral Training in Systems ToxicologyT32ES032920 · NIEHS · WEST VIRGINIA UNIVERSITY · PI Timothy R Nurkiewicz · 2022 to 2026
$1.2M
Effects of Light at Night and Disrupted Circadian Rhythms on PainR21AT011238 · NCCIH · WEST VIRGINIA UNIVERSITY · PI NELSON, RANDY J. · 2021 to 2022
$418k
NCCIH NIH HHS R21 AT011238NCCIH NIH HHS R21-AT011238NIEHS NIH HHS R01 ES031253NIEHS NIH HHS R01-ES031253NIEHS NIH HHS T32 ES032920NIEHS NIH HHS T32-ES032920NIGMS NIH HHS P20 GM103434NIGMS NIH HHS P20-GM103434U.S. Department of Veterans Affairs VA I01 BX006614
6 · The paper itself

Abstract

Millions of U.S. troops and supporting personnel have been deployed to military bases in the Middle East. Essentially all personnel on military bases were exposed to the combustion emissions generated by open pit waste burning. Chronic multisymptom illness (CMI) is a term advanced to characterize the complex health effects of inhalation exposures to military burn pits (BP). Because of the diversity of geography, environmental conditions, and deployment operations, it is very challenging to estimate the number of Veterans affected by CMI, but it has been reported to be in the range of ~ 40-60%. Despite this overwhelming number of patients, the underlying causes of CMI remain to be identified. The purpose of this study was to replicate BP combustion and deliver these representative emissions to a whole-body inhalation exposure chamber with Sprague Dawley rats. We hypothesized that because the microcirculation is a critical component of health and disease, that normal microvascular function may be disrupted after BP inhalation exposures. A surrogate BP emission generator was used to combust mixtures of wood, rubber, plastic and jet fuel. Resultant emissions were complex mixtures of volatile organic chemicals, polyaromatic hydrocarbons, fine and ultrafine particles. The particle aerodynamic count median diameter was 113 nm with a geometric standard deviation of 2.21. The particle mobility diameter was 78.1 nm with a geometric standard deviation of 1.69. The aerosol mass-size size distribution had a mass median aerodynamic diameter of 288 nm with a geometric standard deviation of 1.72 nm. Rats were exposed for ~ 4 h/d at BP emission concentrations of 15.4 ± 1.6 mg/m

Indexed as

Air PollutantsInhalation ExposureLungMicrocirculationMicrovesselsParticulate MatterAnimalsMaleOpen Waste BurningOxidative StressParticle SizeRatsRats, Sprague-DawleyAir PollutantsParticulate MatterInhalation exposureMechanismsMicrocirculationMilitary burn pit

Identifiers

PMID42286691
PMCPMC13501818

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.