ReviewBioMed research international2026
The Importance of 14-3-3 Proteins in Colorectal Cancer Regulation: Mechanisms of Function and Clinical Opportunities.
Review in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Importance of 14-3-3 Proteins in Colorectal Cancer Regulation: Mechanisms of Function and Clinical Opportunities.BioMed research international · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) is the third most frequent cancer and one of the deadliest cancers, with a significant global disease burden. Despite progress in the diagnosis and treatment of CRC, the rate of mortality is still high. Identifying the molecular mechanisms contributing to CRC development and progression creates opportunities to provide better management for CRC. 14-3-3 proteins are extremely conserved phosphoserine/phosphothreonine-binding proteins found in all eukaryotic cells. These proteins regulate a number of biological processes in the cells by binding to their client proteins. Thereby, they can contribute to the regulation of cell cycle progression, proliferation, invasion, and metastasis, highlighting their role in cancer development, progression, and treatment. The present article is aimed at reviewing the 14-3-3 proteins and their biological function, as well as their contribution to cancer regulation. In addition, it will collect previously performed studies investigating the role of 14-3-3 proteins in CRC pathogenesis, emphasizing their potential for diagnostic, prognostic, and therapeutic purposes, offering insights into novel intervention strategies and personalized medicine approaches for CRC.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.