Evidence map›Paper›PMID 42287124›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis.

Shan-Shan Rao, Hai-Jin Zeng, Zun Wang, Chun-Gu Hong, Yi-Juan Tan, Yan-Xin Duan, Jing-Yao Luo, Ming-Jie Luo, Yi-Wei Liu, Xin Wang and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Shan-Shan RaoDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hai-Jin ZengDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zun WangDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chun-Gu HongDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yi-Juan TanDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yan-Xin DuanDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jing-Yao LuoDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ming-Jie LuoExperimental Center of Nursing School, Xinjiang Medical University, Urumqi, Xinjiang, China.
Yi-Wei LiuDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xin WangDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yi LuoDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Teng-Fei WanDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yong ZhouDepartment of Orthopaedics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zheng-Guang WangDepartment of Orthopaedics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Guo-Wen HuDepartment of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Hao YinDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xin-Yue HuDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhen-Xing WangDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ze-Hui HeDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Si-Yi ChengDepartment of P.E, Central South University, Changsha, Hunan, China.
Wei DuDepartment of Rehabilitation, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhe GuanDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hai-Li LangDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Hong-Ji LiuDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jia CaoDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Peng ChenDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jiang-Hua LiuDepartment of Orthopaedics, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Hui XieDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID https://orcid.org/0000-0002-8526-2637
Chun-Yuan ChenDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Funding

Central South University Innovation-Driven Research Programme 2023CXQD001China Postdoctoral Science Foundation 2023M733956China Postdoctoral Science Foundation 2023T160739Jiangxi Province's Science and Technology Agency Support Program 20224ACB216007National Natural Science Foundation of China 82072504National Natural Science Foundation of China 82101463National Natural Science Foundation of China 82125023National Natural Science Foundation of China 82172501National Natural Science Foundation of China 82272565National Natural Science Foundation of China 82372479National Natural Science Foundation of China 82402881Natural Science Foundation of Hunan Province 2023JJ10094Natural Science Foundation of Hunan Province 2024JJ6668Postdoctoral Fellowship Program of CPSF GZB20230871Postgraduate Innovative Project of Central South University 2024ZZTS0925Postgraduate Innovative Project of Central South University 2025ZZTS0351Youth Science Foundation of Xiangya Hospital 2022Q07Youth Science Foundation of Xiangya Hospital 2023Q15
6 · The paper itself

Abstract

Emerging evidence suggests that gut microbiota-derived signals can influence distant organs including the skeleton, yet the key microbial effectors remain elusive. Here, we identify Amuc_1473, a previously uncharacterized protein enriched in extracellular vesicles (EVs) from the commensal bacterium Akkermansia muciniphila (Akk), as a critical mediator of gut-bone communication. Amuc_1473 directly promotes osteogenesis and suppresses osteoclastogenesis by binding to negative elongation factor E (NELF-E) and ribosomal protein L26 (RPL26), regulators of transcriptional pausing and mRNA translation, respectively. Notably, Amuc_1473 levels decline in bone and circulation under diverse pro-osteoporotic conditions-including aging, estrogen deficiency, mechanical unloading, high-fat diet, smoking, alcohol, and chronic stress-paralleling reductions in Akk and its EVs. Intermittent fasting robustly restores Akk abundance, Amuc_1473 levels, and bone quality in these models, via enhanced mucin production. Our findings establish Amuc_1473 as a microbial effector that systemically regulates bone homeostasis, offering a translatable strategy to prevent or treat multifactorial osteoporosis.

Indexed as

Bacterial ProteinsBone and BonesGastrointestinal MicrobiomeHomeostasisOsteogenesisOsteoporosisAkkermansiaAnimalsExtracellular VesiclesMiceMice, Inbred C57BLBacterial Proteinsakkermansia muciniphilaamuc_1473extracellular vesiclesintermittent fastingosteoporosis

Identifiers

PMID42287124
PMCPMC13335810

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.