SynthesisEpilepsia2026
Multidomain neuropsychiatric outcomes after epilepsy surgery: A systematic review and meta-analysis of depression, psychosis, cognition, and psychosocial adjustment.
Synthesis in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
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Abstract
objectiveTo systematically evaluate neuropsychiatric outcomes-depression, anxiety, psychosis, cognition, quality of life, and psychosocial adjustment-following epilepsy surgery in adults, and to quantify pooled effect sizes.
methodsWe searched MEDLINE, Embase, PsycINFO, and the Cochrane Library from inception through December 2024, Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA 2020). Eligible cohort studies (prospective or retrospective) reported standardized neuropsychiatric outcomes in adults undergoing epilepsy surgery with ≥3 month follow-up. Random-effects meta-analyses (DerSimonian-Laird) pooled continuous outcomes as Hedges' g and dichotomous outcomes as proportions (Freeman-Tukey transformation). Heterogeneity (I
resultsForty-two studies (n = 6218) met the inclusion criteria; 26 contributed to quantitative meta-analyses. Pooled depression improvement was small-to-moderate (Standardized Mean Difference (SMD) = -.24; 95% confidence interval [CI] -.34 to -.14; k = 12; I SIGNIFICANCE: Epilepsy surgery produces measurable improvements in depression, psychosis, and quality of life, with seizure freedom as the primary determinant. De novo psychiatric disorders in a substantial minority underscore the need for presurgical screening and longitudinal postoperative monitoring. By integrating evidence across five outcome domains-including psychosocial adjustment, not quantitatively synthesized in prior reviews-this meta-analysis offers a comprehensive framework for informed surgical counseling.
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