ArticleJACC. Case reports2026
Baseline Hypohaptoglobinemia as a Predisposing Factor for Hemolysis-Related Acute Kidney Injury After Pulsed-Field Ablation.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
backgroundHemolysis-related acute kidney injury (AKI) is an uncommon but important complication of pulsed-field ablation (PFA) for atrial fibrillation. The role of baseline hypohaptoglobinemia remains unclear. CASE SUMMARY: A 53-year-old woman with persistent atrial fibrillation underwent pulmonary vein and superior vena cava isolation using a pentaspline PFA catheter with 60 applications. Periprocedural hydration of approximately 1,500 mL was administered. Baseline serum haptoglobin was markedly low at 11 mg/dL (reference range: 43-180 mg/dL, lower detection limit: 10 mg/dL). Serum creatinine increased from 0.66 to 2.68 mg/dL on day 1 and peaked at 5.16 mg/dL on day 3, requiring temporary hemodialysis. Renal function subsequently recovered to baseline. DISCUSSION: Markedly low baseline haptoglobin may have contributed to susceptibility to severe hemolysis-related AKI, even without an excessively high number of PFA applications. TAKE-HOME MESSAGE: Preprocedural hypohaptoglobinemia may be associated with increased susceptibility to AKI after PFA and may support closer monitoring in selected patients.
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