Evidence map›Paper›PMID 42287477›Full record

ArticleFish physiology and biochemistry2026

SIRT1 improves carbohydrate utilization of largemouth bass (Micropterus salmoides) through the Akt1/FoxO1 pathway.

Xianwei Pan, Shiwen Chen, Yuru Li, Ruoxian Wang, Ye Gong, Xuxiong Huang, Songlin Li, Ning Liu

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Article in Fish physiology and biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Xianwei Pan *International Research Centre for Food and Health, College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, China.
Shiwen Chen *Research Centre of the Ministry of Agriculture and Rural Affairs on Environmental Ecology and Fish Nutrition, Shanghai Ocean University, Shanghai, 201306, China.
Yuru LiInternational Research Centre for Food and Health, College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, China.
Ruoxian WangInternational Research Centre for Food and Health, College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, China.
Ye GongResearch Centre of the Ministry of Agriculture and Rural Affairs on Environmental Ecology and Fish Nutrition, Shanghai Ocean University, Shanghai, 201306, China.
Xuxiong HuangResearch Centre of the Ministry of Agriculture and Rural Affairs on Environmental Ecology and Fish Nutrition, Shanghai Ocean University, Shanghai, 201306, China.
Songlin LiResearch Centre of the Ministry of Agriculture and Rural Affairs on Environmental Ecology and Fish Nutrition, Shanghai Ocean University, Shanghai, 201306, China. slli@shou.edu.cn.
Ning LiuInternational Research Centre for Food and Health, College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, China. nliu@shou.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NAD-dependent deacetylase sirtuin 1 (SIRT1) plays a crucial role in regulating glucose metabolism, making it a potential therapeutic target for diabetes. However, its specific role in ameliorating carbohydrate utilization in carnivorous fish prone to glucose metabolic disorders remains unclear. In the present study, a typical carnivorous fish, largemouth bass were fed low carbohydrate (LC) or high carbohydrate (HC) diet for 8 weeks, followed by histological staining, transcriptomics, blood glucose and glycogen assays, RT-qPCR, and Western blot analysis. The results of the in vivo study demonstrated the limited carbohydrate utilization of this fish species, and high carbohydrate led to abnormal hepatic glycogen deposition, and insulin resistance with the depression of SIRT1. Primary hepatocytes cultured study and hepatic transcriptome analyses confirmed high carbohydrate-induced insulin resistance in vitro, and the role of SIRT1 in improving carbohydrate utilization has been confirmed which was suggested to be mediated by the insulin signal pathway. Meanwhile, the activation of insulin pathway under high glucose condition improved the glucose metabolism and the inactivation of Akt1 attenuates the role of SIRT1 in improving glucose utilization. Additionally, SIRT1 promoted Akt1 and FoxO1 phosphorylation, thereby inhibiting FoxO1's transcriptional activity on gluconeogenic genes and alleviating glycogen accumulation. These findings highlight the critical role of the SIRT1 pathway in improving carbohydrate utilization via the Akt1/FoxO1 pathway and suggest potential strategies to mitigate insulin resistance in carnivorous fish.

Indexed as

BassCarbohydrate MetabolismDietary CarbohydratesProto-Oncogene Proteins c-aktSirtuin 1AnimalsBlood GlucoseDietForkhead Box Protein O1Forkhead Transcription FactorsGene Expression RegulationGlucoseHepatocytesInsulinInsulin ResistanceLiverBlood GlucoseDietary CarbohydratesForkhead Box Protein O1Forkhead Transcription FactorsGlucoseInsulinProto-Oncogene Proteins c-aktSirtuin 1Glucose metabolismGlycogen accumulationInsulin resistanceLargemouth bassSIRT1/Akt1/FoxO1

Identifiers

PMID42287477

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.