ArticleCNS drugs2026
Cannabis and Cannabinoid-Related Suspected Adverse Drug Reactions: Global Patterns and Cross-National Analysis Based on VigiBase
Article in CNS drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesDespite increasing global use of cannabis and cannabinoids, comprehensive data on their safety profile remain limited. This study aimed to examine global patterns in pharmacovigilance reports associated with cannabis and cannabinoids, irrespective of regulatory status or context of use.
methodsVigiBase
resultsAmong 7,007,689 records, 9983 cannabis ICSRs were identified across 44 countries, comprising 12,538 cannabis or cannabinoid mentions and 27,593 suspected ADRs. The median age was 29 years, with 62.7% males. Most cases were serious (68.5%), including hospitalisation (45.9%) and death (28.6%). The highest reporting rates relative to national ICSR numbers were observed in France, Greece, and the USA. The most frequently reported substances were Cannabis sativa (n = 5951) and cannabidiol (n = 2967). Suspected ADRs were predominantly psychiatric (29.2%) and nervous system disorders (16.8%), with gastrointestinal, respiratory, and cardiac disorders less common (6.4%, 3.6%, and 2.8%).
conclusionsThis study provides the first comprehensive global overview of suspected ADRs associated with cannabis and cannabinoids. The predominance of serious cases, particularly psychiatric and nervous system reactions, highlights important safety considerations, offering key insights to inform clinical practice and risk assessment worldwide.
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Registered trials
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