Evidence map›Paper›PMID 42289622›Full record

ArticleCardiovascular toxicology2026

Role of L-Arginine and Tetrahydrobiopterin in Attenuation of Vascular Ang1-8 Reactivity via Endothelial PI3K/AKT/eNOS Signaling Pathways in HgCl2-Induced Vascular Dysfunction. An Ex-Vivo Study.

Zana Hassan Ibrahim, Ridha Hassan Hussein, Ismail Mustafa Maulood

Abstract read
PubMed Publisher
In one paragraph

Article in Cardiovascular toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zana Hassan IbrahimDepartment of Medical Laboratory Science, College of Science, University of Raparin, Ranya, Kurdistan Region, Iraq. zana@uor.edu.krd.ORCID http://orcid.org/0009-0002-6321-9598
Ridha Hassan HusseinDepartment of Biology, College of Science, Sulaimani University, Sulaymaniyah, Kurdistan Region, Iraq.ORCID http://orcid.org/0000-0003-1475-5917
Ismail Mustafa MauloodDepartment of Biology, College of Science, Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq.ORCID http://orcid.org/0000-0002-0905-6604

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular endothelial dysfunction because of environmental mercuric chloride (HgCl

Indexed as

Aorta, ThoracicArginineBiopterinsEndothelial CellsEndothelium, VascularMercuric ChlorideNitric Oxide Synthase Type IIIPeptide FragmentsPhosphatidylinositol 3-KinaseProto-Oncogene Proteins c-aktVasodilationAnimalsMaleNitric OxideOxidative StressRats, Sprague-DawleyArginineBiopterinsMercuric ChlorideNitric OxideNitric Oxide Synthase Type IIINos3 protein, ratPeptide FragmentsPhosphatidylinositol 3-KinaseProto-Oncogene Proteins c-aktsapropterinAngiotensin 1-8Endothelial dysfunctionHgCl2l-arginineOxidative stressPI3K/AKT/eNOSTetrahydrobiopterin

Identifiers

PMID42289622

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.