Evidence mapPaperPMID 42290656Full record

ArticleGenes & diseases2026

Transcription cofactor Hes6 interacts with Twist1 to facilitate EMT and promote gastric carcinogenesis by activating the PI3K/AKT signaling.

Can Fang, Zhiwei Peng, Yaru Sang, Zihao Ren, Kang Wang, Nuo Xu, Ying Li, Tingting Guo, Yinan Zhu, Shangxue Yan and 1 more

Abstract read
In one paragraph

Article in Genes & diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Can FangDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China.
Zhiwei PengDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China.
Yaru SangDepartment of Otolaryngology Head and Neck Surgery, Nantong First People's Hospital, Nantong, Jiangsu 226001, China.
Zihao RenDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China.
Kang WangInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Hefei, Anhui 230032, China.
Nuo XuInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Hefei, Anhui 230032, China.
Ying LiInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Hefei, Anhui 230032, China.
Tingting GuoInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Hefei, Anhui 230032, China.
Yinan ZhuDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China.
Shangxue YanInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Hefei, Anhui 230032, China.
Kongwang HuDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advanced gastric cancer (GC) poses a significant threat to public health, leading to substantial consumption of healthcare resources due to its aggressive nature and poor prognosis. Hairy and enhancer of split 6 (Hes6), a member of the mammalian homologs of

Indexed as

EMTGastric cancerHes6PI3K/AKT pathwayTwist1

Identifiers

PMID42290656
PMCPMC13264254

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.