ArticleJournal of Taibah University Medical Sciences2026
The potential of calcitriol gel in accelerating the healing of traumatic oral ulcers.
Article in Journal of Taibah University Medical Sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
Objectives: This study was aimed at evaluating the effects of topical calcitriol gel on traumatic oral ulcer healing, by assessing inflammatory, proliferative, and angiogenic responses in an in vivo rat model. Methods: Traumatic ulcers were induced in Wistar rats ( Results: Calcitriol-treated ulcers, compared with those in the control group, demonstrated significantly greater macrophage infiltration on day 6 (p = 0.045) and day 8 (p = 0.031), as well as significantly higher lymphocyte counts on day 6 (p = 0.033) and day 8 (p = 0.021). In addition, fibroblast proliferation, collagen deposition, and capillary density were significantly greater in the treatment group than the control group (p < 0.05). VEGF expression peaked on day 6 (p = 0.023), thus indicating enhanced angiogenic activity. Conclusions: Topical calcitriol gel significantly enhanced healing in traumatic oral ulcers by modulating inflammatory responses, promoting fibroblast activity, and stimulating angiogenesis. These findings support its potential as a therapeutic agent for oral mucosal repair.
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