Evidence map›Paper›PMID 42290906›Full record

ArticleKidney international reports2026

Contrast-Associated AKI in Hospitalized Adults With Sickle Cell Disease.

Loris Azoyan, Yannis Lombardi, Pablo Bartolucci, François Lionnet, Christelle Chantalat Auger, Sylvain Le Jeune, Louis Affo, Jean-Benoît Arlet, Jean-Philippe Haymann, Judith Leblanc and 1 more

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Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Loris AzoyanRéseau Sentinelles, Institut Pierre Louis d'Epidémiologie et de Santé Publique, INSERM, Sorbonne Université, Paris, France.
Yannis LombardiRéseau Sentinelles, Institut Pierre Louis d'Epidémiologie et de Santé Publique, INSERM, Sorbonne Université, Paris, France.
Pablo BartolucciCentre de référence de la drépanocytose et des maladies du globule rouge, Hôpital Henri Mondor, Assistance Publique - Hôpitaux de Paris, Créteil, France.
François LionnetService de Médecine Interne, Hôpital Tenon, Assistance Publique - Hôpitaux de Paris, Paris, France.
Christelle Chantalat AugerService de Médecine Interne, Hôpital Kremlin-Bicêtre, Assitance Publique - Hôpitaux de Paris, Kremlin-Bicêtre, France.
Sylvain Le JeuneService de Médecine Interne, Hôpital Avicenne, Assistance Publique - Hôpitaux de Paris, Université Sorbonne Paris Nord, Bobigny, France.
Louis AffoService de Médecine Interne, Hôpital Louis Mourier, Assistance Publique - Hôpitaux de Paris, Colombes, France.
Jean-Benoît ArletService de Médecine Interne, Hôpital Européen Georges Pompidou, Assistance Publique - Hôpitaux de Paris, Université Paris Cité, Paris, France.
Jean-Philippe HaymannExplorations fonctionnelles multidisciplinaires, Hôpital Tenon, Assistance Publique - Hôpitaux de Paris, Paris, France.
Judith LeblancInstitut Pierre Louis d'Epidémiologie et de Santé Publique, Sorbonne Université, INSERM, Paris, France.
Olivier SteichenRéseau Sentinelles, Institut Pierre Louis d'Epidémiologie et de Santé Publique, INSERM, Sorbonne Université, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Patients with sickle cell disease (SCD) are at risk of chronic kidney disease (CKD) and acute kidney injury (AKI). The risk of AKI associated with contrast media (CM) exposures in this population is uncertain. The objective of this study was to investigate this temporal association in a multicentric case series. Methods: We performed a retrospective self-controlled case series (SCCS) in adults followed-up in SCD centers of the Greater Paris University Hospitals who experienced AKI during hospitalization between 2013 and 2022. SCCS estimates the relative incidence (RI) of events during exposure periods (around CM exposure) compared with control periods within the same individual. Analyses were restricted to hospitalizations periods and accounted for time-varying confounders such as age, presence of albuminuria, reduced estimated glomerular filtration rate, and stay in a medical ward or intensive care unit (ICU). Results: In the main analysis, that included 529 patients and 755 cases of AKI, AKI incidence increased significantly during the 7-day pre-exposure period (RI: 2.53, 95% confidence interval [CI]: 2.02-3.16), the 0 to 3 days postexposure (RI: 2.52, 95% CI: 1.99-3.19) and the 4 to 7 days postexposure (RI: 1.57, 95% CI: 1.20-2.06). Similar patterns were observed for stage 2 or 3 AKI, with higher RI. Conclusion: In this cohort of hospitalized adults with SCD, mainly young patients with preserved kidney function and few comorbidities, the RI of AKI was twice as high both before and after CM exposure, suggesting the role of underlying clinical conditions and related medical interventions rather than a causal effect of CM.

Indexed as

acute kidney injurycontrast mediasickle cell disease

Identifiers

PMID42290906
PMCPMC13264182

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.