Evidence map›Paper›PMID 42290973›Full record

ArticleBioactive materials2026

Bioengineered titanium implants functionalized with aptamer-valproic acid conjugates orchestrate macrophage programming and mesenchymal stem cell homing for improved osseointegration.

Danhe Sun, Quan Zhou, Xiaoling Guo, Hang Shi, Xiaoyan Wang, Xinkai Li, Zhihuang Zheng, Linfeng Zhong, Senhu Cao, Ruifan Shan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Danhe SunDepartment of Stomatology, Air Force Medical Center, PLA, The Fourth Military Medical University, Beijing, 100142, China.
Quan ZhouDepartment of Stomatology, Air Force Medical Center, PLA, The Fourth Military Medical University, Beijing, 100142, China.
Xiaoling GuoDepartment of Stomatology, Air Force Medical Center, PLA, The Fourth Military Medical University, Beijing, 100142, China.
Hang ShiDepartment of Stomatology, Air Force Medical Center, PLA, The Fourth Military Medical University, Beijing, 100142, China.
Xiaoyan WangDepartment of Stomatology, Air Force Medical Center, PLA, The Fourth Military Medical University, Beijing, 100142, China.
Xinkai LiDepartment of Stomatology, Air Force Medical Center, PLA, The Fourth Military Medical University, Beijing, 100142, China.
Zhihuang ZhengDepartment of Stomatology, Air Force Medical Center, PLA, The Fourth Military Medical University, Beijing, 100142, China.
Linfeng ZhongSchool of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China.
Senhu CaoDepartment of Stomatology, Air Force Medical Center, PLA, The Fourth Military Medical University, Beijing, 100142, China.
Ruifan ShanDepartment of Stomatology, Air Force Medical Center, PLA, The Fourth Military Medical University, Beijing, 100142, China.
Zexu SuMedical School of Chinese PLA, Beijing, 100853, China.
Chufan MaDepartment of Stomatology, Air Force Medical Center, PLA, The Fourth Military Medical University, Beijing, 100142, China.
Lingzhou ZhaoDepartment of Stomatology, Air Force Medical Center, PLA, The Fourth Military Medical University, Beijing, 100142, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional titanium implants often exhibit limited bioactivity, failing to adequately modulate the immune response and promote endogenous regeneration, which leads to suboptimal osseointegration. To address this, we developed a multifunctional implant (NTP/Apt-VPA) by conjugating Apt19s-an mesenchymal stem cell (MSC)-specific aptamer-with valproic acid (VPA), anchored onto a polydopamine-coated TiO

Indexed as

ImmunomodulationMacrophage polarizationMesenchymal stem cell homingOsseointegrationTitanium implants

Identifiers

PMID42290973
PMCPMC13264186

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.