Evidence map›Paper›PMID 42291205›Full record

ArticleiScience2026

VTA dopamine inputs activate accumbal D1 receptors to promote alcohol seeking.

Junwei Xiong, Mengyao Dou, Xinxin Li, Ting Zeng, Yongliang Liu, Huizhen Dai, Chenyu Du, Xiaowei Shi, Xiangmin Xu, Xiaofei Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Junwei XiongDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang 157011, China.
Mengyao DouDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang 157011, China.
Xinxin LiDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang 157011, China.
Ting ZengHeilongjiang Province Key Laboratory of Mechanism and Prevention of Substance Dependence Disease, Mudanjiang 157011, China.
Yongliang LiuDevelopment Anesthesiology, Mudanjiang Medical University, Mudanjiang 157011, China.
Huizhen DaiDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang 157011, China.
Chenyu DuDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang 157011, China.
Xiaowei ShiDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang 157011, China.
Xiangmin XuDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang 157011, China.
Xiaofei WangDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang 157011, China.
Xiaofeng ZhuDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang 157011, China.
Jianing WeiDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang 157011, China.
Dandan CuiDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang 157011, China.
Yanzhong GuanDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang 157011, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mesolimbic dopamine system is central to cue-induced alcohol craving, but the role of D1 receptors (D1R) in the nucleus accumbens (NAc) remains unclear. Here, we show that cue-induced, but not context-elicited, alcohol seeking selectively upregulates NAc D1R protein expression in mice, which positively correlates with craving intensity. Systemic D1R antagonist SCH23390 suppresses cue-induced seeking and reverses c-Fos activation in the NAc and ventral pallidum. Chemogenetic inhibition of ventral tegmental area (VTA) dopamine neurons attenuates craving, an effect fully rescued by intra-NAc D1R agonist SKF38393 without affecting locomotion. These findings establish that dopaminergic projections from the VTA to the NAc drive cue-specific alcohol seeking through D1 receptor-dependent manner.

Indexed as

PaleobiologyPaleogeneticsPhylogeneticsZoology

Identifiers

PMID42291205
PMCPMC13254849

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.