Evidence map›Paper›PMID 42291255›Full record

ArticleiScience2026

Dim light at night induces cardiac injury in zebrafish embryos via disrupted chloride homeostasis.

Risi Chen, Ying Zeng, Meixin Min, Ke Xu, Jia Wang, Tingting Liu, Yan Zhao, Weixin Zhang, Shuting Cheng, Yiyue Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Risi ChenGanzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000, China.
Ying ZengShenzhen Center for Disease Control and Prevention, Shenzhen 518055, China.
Meixin MinGanzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000, China.
Ke XuGanzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000, China.
Jia WangGanzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000, China.
Tingting LiuGanzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000, China.
Yan ZhaoGanzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000, China.
Weixin ZhangGanzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000, China.
Shuting ChengHealth Ministry Key Laboratory of Chronobiology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.
Yiyue ZhangInnovation Centre of Ministry of Education for Development and Diseases, School of Medicine, South China University of Technology, Guangzhou 510006, China.
Chunru WangBeijing National Research Center for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Science, Beijing 100190, China.
Dan DengGannan Health Vocational College, Ganzhou 341000, China.
Xiaoping XiaoGanzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial light at night (ALAN) is an escalating environmental stressor linked to cardiovascular disease, yet its underlying mechanisms remain poorly understood. Here, we investigate the molecular basis of this pathology using zebrafish embryos for mechanistic discovery and murine models for translational validation under a chronic dim- light- at -night (dLAN) paradigm. dLAN exposure induced cardiac injury characterized by pericardial edema and hemodynamic impairment. Transcriptomic profiling revealed dysregulation of inflammatory and oxidative stress pathways, accompanied by marked suppression of the calcium-activated chloride channel accessory protein

Indexed as

environmental healthmolecular biology

Identifiers

PMID42291255
PMCPMC13255061

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.