Evidence map›Paper›PMID 42291274›Full record

ArticleiScience2026

The lysophosphatidylcholine-HIF-1α axis enhances apolipoprotein E sialylation and promotes electronegative LDL accumulation.

Hua-Chen Chan, Hsiu-Chuan Chan, Liu-Fang Wang, Mei-Lin Chan, Wen-Chien Huang, Daniel Bender, Yu-Min Ko, Ming-Lung Yu, Guan-Ming Ke, Mei-Chuan Chou and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cellular basis of HFpEF: contributions of abnormal lipids.Frontiers in cardiovascular medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hua-Chen ChanDepartment of Medical Laboratory Science, College of Medical Science and Technology, I-Shou University, Kaohsiung 82445, Taiwan.
Hsiu-Chuan ChanPh.D. Program in Life Sciences, College of Life Science, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
Liu-Fang WangDepartment of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
Mei-Lin ChanDepartment of Medical Research, MacKay Memorial Hospital, New Taipei City 104217, Taiwan.
Wen-Chien HuangDepartment of Medical Research, MacKay Memorial Hospital, New Taipei City 104217, Taiwan.
Daniel BenderInstitute of Pathology and Molecular Pathology, University Hospital Zürich, 8091 Zürich, Switzerland.
Yu-Min KoHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
Ming-Lung YuHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
Guan-Ming KeGraduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 912301, Taiwan.
Mei-Chuan ChouGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
Ching-Kuan LiuDepartment of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
Liang-Yin KeDepartment of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electronegative low-density lipoprotein (L5-LDL) drives vascular injury in metabolic syndrome (MetS), yet its hepatic origin remains undefined. Here, we identify a lysophosphatidylcholine (LPC)-hypoxia-inducible factor-1α (HIF-1α) axis that governs apolipoprotein E (apoE) glycosylation and lipoprotein electronegativity. LPC activates HIF-1α in hepatocytes, inducing polypeptide

Indexed as

Cardiovascular medicineLipidomics

Identifiers

PMID42291274
PMCPMC13264260

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.