Evidence map›Paper›PMID 42291280›Full record

ArticleiScience2026

Targeting Rap1-YAP1 mechanosignaling for ameliorating acute IOP elevation-induced trabecular meshwork dysfunction.

Yupeng Zhang, Xue Li, Qiumei Hu, Linlin Luo, Qian Luo, Xiangbin Guan, Jingyi Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yupeng ZhangSchool of Life Sciences, Tsinghua University, Beijing 100084, China.
Xue LiDepartment of Ophthalmology, Institute of Surgery Research, Army Medical Center of PLA (Daping Hospital), Army Medical University, Chongqing 400042, China.
Qiumei HuDepartment of Ophthalmology, Institute of Surgery Research, Army Medical Center of PLA (Daping Hospital), Army Medical University, Chongqing 400042, China.
Linlin LuoDepartment of Ophthalmology, Institute of Surgery Research, Army Medical Center of PLA (Daping Hospital), Army Medical University, Chongqing 400042, China.
Qian LuoDepartment of Ophthalmology, The General Hospital of Central Theater Command, Wuhan, Hubei Province 430000, China.
Xiangbin GuanDepartment of Ophthalmology, The General Hospital of Central Theater Command, Wuhan, Hubei Province 430000, China.
Jingyi ZhuDepartment of Ophthalmology, The General Hospital of Central Theater Command, Wuhan, Hubei Province 430000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glaucoma is the second leading cause of blindness, and intraocular pressure (IOP) is the principal and only modifiable risk factor. The trabecular meshwork (TM) remains the most important target for IOP regulation; although it is highly mechanosensitive, TM responses to high IOP remain unclear. This study suggested that human TM cells are susceptible to mechanical stimuli using single-cell sequencing; further,

Indexed as

Molecular biologyOphthalmology

Identifiers

PMID42291280
PMCPMC13264258

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.