ArticleFrontiers in cellular and infection microbiology2026
Sex-specific associations between gut microbiota and myopia in adolescents: a clinical predictive modeling study.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Myopia is a common refractive disorder in adolescents, and its association with the gut microbiota remains incompletely defined. Methods: We performed 16S rRNA sequencing on fecal samples from 102 adolescents (49 myopic, 53 non-myopic; aged 6-18 years) and analyzed microbial diversity, taxonomy, function, and random forest-based classification, stratified by sex. Results: Myopic adolescents showed lower gut microbial richness (observed and Chao1, both P < 0.05) than non-myopic controls, but overall community structure did not differ. Sex-stratified analyses revealed that these diversity reductions occurred only in myopic males (all α-diversity indices, P < 0.01), not in females. Several genera differed between myopic and non-myopic males (e.g., lower Akkermansia, Alistipes, Oscillibacter; higher Veillonella, Sutterella), whereas fewer differences were found in females. Functional predictions indicated altered metabolism and immune pathways. A random forest model achieved moderate overall accuracy (AUC = 76.84%), with higher performance in males (89.13%) than females (69.21%). Discussion: Adolescent myopia is associated with reduced gut microbial richness and sex-specific compositional changes, particularly in males, underscoring the importance of sex in gut-eye axis research.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.