Evidence map›Paper›PMID 42291502›Full record

ArticleBiochemistry and biophysics reports2026

Salvianolic acid B mitigates senescence and promotes osteogenesis of senescent bone marrow mesenchymal stem cells via the PI3K/AKT pathway.

Shaozi Zhong, Dianxuan Wu, Qize Chen, Chun Zeng, Huabin Chen, Jie Huang

Abstract read
In one paragraph

Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shaozi ZhongDepartment of Sports Medicine, Center for Orthopedic Surgery, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital, Southern Medical University, 183 Zhongshan Avenue West, Guangzhou, Guangdong, 510630, PR China.
Dianxuan WuDepartment of Sports Medicine, Center for Orthopedic Surgery, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital, Southern Medical University, 183 Zhongshan Avenue West, Guangzhou, Guangdong, 510630, PR China.
Qize ChenDepartment of Sports Medicine, Center for Orthopedic Surgery, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital, Southern Medical University, 183 Zhongshan Avenue West, Guangzhou, Guangdong, 510630, PR China.
Chun ZengDepartment of Sports Medicine, Center for Orthopedic Surgery, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital, Southern Medical University, 183 Zhongshan Avenue West, Guangzhou, Guangdong, 510630, PR China.
Huabin ChenDepartment of Sports Medicine, Center for Orthopedic Surgery, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital, Southern Medical University, 183 Zhongshan Avenue West, Guangzhou, Guangdong, 510630, PR China.
Jie HuangDepartment of Stomatology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, 111 Dade Road, Guangzhou, Guangdong, 510120, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Senescence is a major contributor to osteoporosis, with progressive bone loss in later life characterizing age-related osteoporosis. The decline in bone marrow mesenchymal stem cells (BMSCs) function, particularly the reduction in osteogenic capacity, plays a central role in this process. Therefore, improving the function of senescent BMSCs could potentially slow the age-related osteoporosis progression. Salvianolic acid B (Sal-B), the most abundant and bioactive water-soluble compound derived from the traditional herb

Indexed as

Bone marrow mesenchymal stem cellOsteogenic differentiationPI3K/AKT pathwaySalvianolic acid BSenescence

Identifiers

PMID42291502
PMCPMC13254721

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.